Human DC-STAMP Antibody
R&D Systems, part of Bio-Techne | Catalog # MAB7824
Key Product Details
Validated by
Species Reactivity
Applications
Label
Antibody Source
Product Specifications
Immunogen
Asp314-Thr376
Accession # Q9H295
Specificity
Clonality
Host
Isotype
Scientific Data Images for Human DC-STAMP Antibody
Detection of DC-STAMP in Human Mature Dendritic Cells by Flow Cytometry.
Human mature dendritic cells derived from CD14+Human peripheral blood mononuclear cells (PBMCs) treated with 20 ng/mL Recombinant Human IL-4 (Catalog # 204-IL) and 50 ng/mL Recombinant Human GM-CSF (Catalog # 215-GM) for 6 days then treated with 20 ng/mL LPS, 20 ng/mL Recombinant Human TNF-a (Catalog # 210-TA), and 20 ng/mL Recombinant Human IL-1 beta (Catalog # 201-LB) for 24 hours were stained with Mouse Anti-Human CD83 Fluorescein-conjugated Monoclonal Antibody (Catalog # FAB1774F) and either (A) Mouse IgG2BIsotype Control (Catalog # MAB0041) or (B) Mouse Anti-Human DC-STAMP Monoclonal Antibody (Catalog # MAB7824) followed by Allophycocyanin-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # F0101B).Applications for Human DC-STAMP Antibody
CyTOF-ready
Flow Cytometry
Sample: Human mature dendritic cells derived from CD14+ Human peripheral blood mononuclear cells (PBMCs) treated with Recombinant Human IL-4 (Catalog # 204-IL) and Recombinant Human GM-CSF (Catalog # 215-GM) for 6 days then treated with LPS, Recombinant Human TNF-alpha (Catalog # 210-TA), and Recombinant Human IL-1 beta (Catalog # 201-LB) for 24 hours
Formulation, Preparation, and Storage
Purification
Reconstitution
Formulation
Shipping
Stability & Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: DC-STAMP
DC-STAMP, also known as TM7SF4, is an approximately 50 kDa glycoprotein with seven transmembrane segments. It is expressed on the surface of dendritic cells and monocytes as well as on osteoclasts and their progenitors. DC-STAMP binds CTGF/CCN2 and cooperates with TRANCE/RANK L for inducing osteoclast differentiation and fusion into multinucleated cells. It contains a cytoplasmic immunoreceptor tyrosine-based inhibitory motif (ITIM) and associates with FC gamma RIII/CD16. Within aa 314-376, human DC-STAMP shares approximately 75% aa sequence identity with mouse and rat DC-STAMP.
Long Name
Alternate Names
Gene Symbol
UniProt
Additional DC-STAMP Products
Product Documents for Human DC-STAMP Antibody
Product Specific Notices for Human DC-STAMP Antibody
For research use only