Human GPR88 Antibody

R&D Systems, part of Bio-Techne | Catalog # MAB10828

R&D Systems, part of Bio-Techne
Catalog #
Availability
Size / Price
Qty
MAB10828-100
MAB10828-SP
Print Quote
Bulk Order
100% Guarantee

Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # 1039830

View all GPR88 Antibodies »

Product Specifications

Immunogen

Human GPR88 synthetic peptide

Specificity

Detects human GPR88 in direct ELISAs.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Scientific Data Images for Human GPR88 Antibody

GPR88 in Human Brain (Caudate Nucleus).

GPR88 was detected in immersion fixed paraffin-embedded sections of human brain (caudate nucleus) using Mouse Anti-Human GPR88 Monoclonal Antibody (Catalog # MAB10828) at 5 µg/mL for 1 hour at room temperature followed by incubation with the Anti-Mouse IgG VisUCyte™ HRP Polymer Antibody (VC001). Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic (CTS013). Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized to neuronal cell bodies and processes. Staining was performed using our protocol for IHC Staining with VisUCyte HRP Polymer Detection Reagents.

Applications for Human GPR88 Antibody

Application
Recommended Usage

Immunohistochemistry

5-25 µg/mL
Sample: Immersion fixed paraffin-embedded sections of human brain (caudate nucleus)

Formulation, Preparation, and Storage

Purification

Protein A or G purified from hybridoma culture supernatant

Reconstitution

Reconstitute at 0.5 mg/mL in sterile PBS. For liquid material, refer to CoA for concentration.

Reconstitution Buffer Available:
Size / Price
Qty

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Shipping

Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: GPR88

GPR88 is an orphan receptor that probably belongs to the G-protein coupled receptor family.  Ligands for this receptor still largely remain unknown but agonists have been discovered.  It is a brain-specific receptor with almost exclusive expression in the striatum, being preferentially localized in medium spiny neurons.  Because of its expression, GPR88 is emerging as a drug target for CNS disorders such as schizophrenia, Parkinson's disease, anxiety, and addiction. Gpr88 KO mice data suggests that striatal GPR88 receptors influence activity in a range of procedures integrated by prefrontal, orbitofrontal and anterior cingulate cortico-striatal-thalamic loops leading to altered cognitive, motivational and reward evaluation processes.

Long Name

G Protein-coupled Receptor 88

Alternate Names

STRG

Entrez Gene IDs

54112 (Human); 64378 (Mouse); 64443 (Rat)

Gene Symbol

GPR88

Additional GPR88 Products

Product Documents for Human GPR88 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Note: Certificate of Analysis not available for kit components.

Download SDS

Product Specific Notices for Human GPR88 Antibody

For research use only

Privacy and Cookie Policy
Site Map
© Copyright 2024 Bio-Techne. All Rights Reserved.