Human HNF-4 alpha/NR2A1 MAb (Cl H1415) (Protein A Purified)
R&D Systems, part of Bio-Techne | Catalog # PP-H1415-0C
Key Product Details
Species Reactivity
Validated:
Human
Cited:
Human, Mouse
Applications
Validated:
Chromatin Immunoprecipitation (ChIP), Direct ELISA, Gel Supershift Assay, Immunohistochemistry, Immunoprecipitation, Western Blot
Cited:
Chromatin Immunoprecipitation (ChIP), Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Western Blot
Label
Unconjugated
Antibody Source
Monoclonal Mouse IgG2A Clone # H1415
Product Specifications
Clonality
Monoclonal
Host
Mouse
Isotype
IgG2A
Applications for Human HNF-4 alpha/NR2A1 MAb (Cl H1415) (Protein A Purified)
Application
Recommended Usage
Chromatin Immunoprecipitation (ChIP)
Direct ELISA
Gel Supershift Assay
Immunohistochemistry
Immunoprecipitation
Western Blot
Please Note: Optimal dilutions of this antibody should be experimentally determined.
Formulation, Preparation, and Storage
Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store the unopened product at -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Background: HNF-4 alpha/NR2A1
Hepatocyte Nuclear Factor 4 alpha (HNF4 alpha; NR2A1) is a member of the orphan nuclear receptor family. HNF4 alpha is expressed in the liver, kidney, intestine and pancreas. Mutation of HNF4 alpha in humans has been associated with maturity-onset diabetes of the young type 1 (MODY1). HNF4 binds to DNA as an exclusive homodimer. The HNF4 alpha gene is alternatively spliced and may generate up to nine different isoforms, HNF4 alpha 1 through HNF4 alpha 9. The expression of HNF-4 gamma (NR2A2) is observed in the pancreas, kidney, small intestine, and testes with no expression detected in the liver. The level of HNF-4 gamma is less 10% than that of HNF-4 alpha.
Long Name
Hepatocyte Nuclear Factor-4, alpha
Alternate Names
HNF4 alpha, HNF4A, MODY1, NR2A1, TCF14
Entrez Gene IDs
3172 (Human)
Gene Symbol
HNF4A
Additional HNF-4 alpha/NR2A1 Products
Product Documents for Human HNF-4 alpha/NR2A1 MAb (Cl H1415) (Protein A Purified)
Product Specific Notices for Human HNF-4 alpha/NR2A1 MAb (Cl H1415) (Protein A Purified)
For research use only
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