Human IL-17/IL-17A (Research Grade Secukinumab Biosimilar) Antibody

R&D Systems, part of Bio-Techne | Catalog # MAB9492

Recombinant Monoclonal Antibody For Research Use Only
R&D Systems, part of Bio-Techne
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MAB9492-SP
MAB9492-100
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Key Product Details

Species Reactivity

Human

Applications

ELISA

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Human IgG1 Clone # Hu71

View all IL-17/IL-17A Antibodies »

Product Specifications

Immunogen

Human IL‑17/IL‑17A

Clonality

Monoclonal

Host

Human

Isotype

IgG1

Scientific Data Images for Human IL-17/IL-17A (Research Grade Secukinumab Biosimilar) Antibody

Human IL-17/IL-17A ELISA Standard Curve

Direct ELISA binding curve demonstrating the recognition of Human Anti-Human IL-17/IL-17A (Research Grade Secukinumab Biosimilar) Monoclonal Antibody (Catalog # MAB9492) to IL-17/IL-17A. The target protein was coated onto the microplate well surface, followed by binding of the antibody. A goat anti-human HRP conjugate was used for detection.

Applications for Human IL-17/IL-17A (Research Grade Secukinumab Biosimilar) Antibody

Application
Recommended Usage

ELISA

This antibody functions as an ELISA detection antibody for the specific antigen in direct ELISA. Colorimetric detection is performed after addition of a suitable substrate.

Formulation, Preparation, and Storage

Purification

Protein A or G purified from hybridoma culture supernatant

Reconstitution

Reconstitute at 0.5 mg/mL in sterile PBS. For liquid material, refer to CoA for concentration.

Reconstitution Buffer Available:
Size / Price
Qty

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Shipping

Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: IL-17/IL-17A

Secukinumab is a humanized monoclonal IgG1/k antibody against proinflammatory cytokine IL-17A, and is approved for the treatment of plaque psoriasis, as well as enthesitis-related arthritis, and ankylosing spondylitis.  Secukinumab binds to IL-17A  with high specificity preventing the interaction with the IL-17 receptor and subsequent activation of the pathway leading to inflammation seen in these disease states.  Data has shown that in the presence of secukinumab results in enhanced levels of free unbound IL-17A in the serum indicating inhibition of binding to IL-17A receptor resulting in reduced inflammation.

Long Name

Interleukin 17

Alternate Names

CTLA-8, CTLA8, IL-17A, IL17, IL17A

Entrez Gene IDs

3605 (Human); 16171 (Mouse); 301289 (Rat); 449530 (Porcine); 481837 (Canine); 102119976 (Cynomolgus Monkey)

Gene Symbol

IL17A

Additional IL-17/IL-17A Products

Product Documents for Human IL-17/IL-17A (Research Grade Secukinumab Biosimilar) Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Note: Certificate of Analysis not available for kit components.

Product Specific Notices for Human IL-17/IL-17A (Research Grade Secukinumab Biosimilar) Antibody

For research use only

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