Human IL-17F Antibody

Human IL‑17F cDNA encodes a 163 amino acid (a) protein with a putative 30 aa signal peptide. Among IL‑17 family members, IL‑17F is most closely related to IL‑17A (approximately 44% aa sequence homology), but shares only limited sequence homology (16‑30%) with IL-17B, C, D and E. Human and mouse IL-17F share 55% sequence identity. IL-17F is expressed in activated CD4⁺ T-cells and activated monocytes. Five receptors (IL-17 RA, B, C, D and E) have been identified (5). Although the ligands for IL-17 RD and E are not known yet, it is reported that IL-17 RA binds IL-17A, and IL‑17 RB binds IL‑17B and IL-17E. IL‑17 RC binds IL‑17A and IL‑17F with similarly high affinity and functions as a receptor for both IL‑17A and IL‑17F (5, 6). The biological activities mediated by IL‑17F are similar to those of
IL‑17. IL‑17F stimulates production of IL‑6, IL-8, G-CSF, and regulates cartilage matrix turnover by increasing matrix release and inhibiting new matrix synthesis (4).
IL‑17F also inhibits angiogenesis and induces production of IL‑2, TGF-beta, and monocyte chemoattractant protein‑1 in endothelial cells (3).