Human Integrin beta7 Fluorescein-conjugated Antibody
R&D Systems, part of Bio-Techne | Catalog # FAB4669F
Conjugate
Catalog #
Key Product Details
Species Reactivity
Validated:
Human
Cited:
Human
Applications
Validated:
Flow Cytometry
Cited:
Flow Cytometry
Label
Fluorescein (Excitation = 488 nm, Emission = 515-545 nm)
Antibody Source
Monoclonal Mouse IgG1 Clone # 473207
Product Specifications
Immunogen
Chinese hamster ovary cell line CHO-derived recombinant human Integrin beta7 long isoform
Glu20-His723
Accession # P26010
Glu20-His723
Accession # P26010
Specificity
Detects human Integrin beta7 in direct ELISAs and Western blots. In Western blots, no cross-reactivity with recombinant human Integrin beta1, beta2, beta3, beta4, beta5, beta6, beta8, recombinant mouse Integrin beta4, or beta7 is observed.
Clonality
Monoclonal
Host
Mouse
Isotype
IgG1
Scientific Data Images for Human Integrin beta7 Fluorescein-conjugated Antibody
Detection of Integrin beta7 in PBMCs Lymphocytes by Flow Cytometry.
Human peripheral blood lymphocytes were stained with Mouse Anti-Human Integrin beta7 Fluorescein-conjugated Monoclonal Antibody (Catalog # FAB4669F, filled histogram) or isotype control antibody (Catalog # IC002F, open histogram). View our protocol for Staining Membrane-associated Proteins.Applications for Human Integrin beta7 Fluorescein-conjugated Antibody
Application
Recommended Usage
Flow Cytometry
10 µL/106 cells
Sample: Human peripheral blood lymphocytes
Sample: Human peripheral blood lymphocytes
Formulation, Preparation, and Storage
Purification
Protein A or G purified from hybridoma culture supernatant
Formulation
Supplied in a saline solution containing BSA and Sodium Azide.
Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store the unopened product at 2 - 8° C. Do not use past expiration date. Protect from light.
Background: Integrin beta 7
Human Integrin beta7 (also Integrin betaP and M290 IEL Ag) is a 120 kDa member of the Integrin beta chain family of molecules. It is a type I transmembrane glycoprotein that contains a 704 amino acid (aa) extracellular domain (ECD) (aa 20‑723) and a 52 aa cytoplasmic tail. The ECD contains one von Willebrand factor A domain (aa 150‑389) and four cysteine‑rich EGF‑like repeats. One splice variant exists that shows a deletion of aa 501‑648. Integrin beta7 forms a nondisulfide linked heterodimer with alpha4 and alphaE integrins. alpha4 beta7 binds fibronectin, VCAM-1 and MADCAM1, while alphaE beta7 binds E-cadherin. The ECD of human beta7 is 87% aa identical to the ECD of mouse beta7.
Alternate Names
ITGB7
Gene Symbol
ITGB7
UniProt
Additional Integrin beta 7 Products
Product Documents for Human Integrin beta7 Fluorescein-conjugated Antibody
Product Specific Notices for Human Integrin beta7 Fluorescein-conjugated Antibody
For research use only
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