Human MUC-19 Antibody
R&D Systems, part of Bio-Techne | Catalog # MAB8245
Key Product Details
Species Reactivity
Human
Applications
Immunohistochemistry
Label
Unconjugated
Antibody Source
Monoclonal Mouse IgG1 Clone # 876013
Product Specifications
Immunogen
E. coli-derived recombinant human MUC-19
Lys5606-Gly5767
Accession # Q7Z5P9
Lys5606-Gly5767
Accession # Q7Z5P9
Specificity
Detects human MUC-19 in direct ELISAs.
Clonality
Monoclonal
Host
Mouse
Isotype
IgG1
Scientific Data Images for Human MUC-19 Antibody
MUC‑19 in Human Salivary Gland.
MUC-19 was detected in immersion fixed paraffin-embedded sections of human salivary gland using Mouse Anti-Human MUC-19 Monoclonal Antibody (Catalog # MAB8245) at 15 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Mouse HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS002) and counterstained with hematoxylin (blue). Specific staining was localized to mucosal cells. View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.Applications for Human MUC-19 Antibody
Application
Recommended Usage
Immunohistochemistry
8-25 µg/mL
Sample: Immersion fixed paraffin-embedded sections of human salivary gland
Sample: Immersion fixed paraffin-embedded sections of human salivary gland
Formulation, Preparation, and Storage
Purification
Protein A or G purified from hybridoma culture supernatant
Reconstitution
For liquid material, refer to CoA for concentration.
Formulation
Supplied as a 0.2 μm filtered solution in PBS. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
- 12 months from date of receipt, -20 to -70 °C, as supplied.
- 1 month, 2 to 8 °C under sterile conditions after opening.
- 6 months, -20 to -70 °C under sterile conditions after opening.
Background: MUC-19
MUC-19 is a 6,254 amino acid member of the Mucin family of gel-forming glycoproteins. MUC-19 is expressed in corneal epithelial cells in the eye, conjuctival goblet and epithelial cells and lacrimal gland cells as well as by mucous cells of the submandibular gland and submucosal gland of the trachea. MUC-19 expression is reduced in patients with Sjogren syndrome (1,2). In a middle ear model of inflammatory response, MUC-19 is up-regulated in epithelial cells by exposure to cytokines including TNF-alpha, IL-1 beta, IL-5 and IL-8 (3).
References
- Yu, D. et al. (2008) Exp Eye Res. 86 :403.
- Chen, Y. et al. (2004) Am J Respir Cell Mol Biol 30:155.
- Kerschner, J. et al. (2009) Glycoconj J. 26:1275.
Long Name
Mucin 19, Oligomeric
Alternate Names
MUC19
Entrez Gene IDs
283463 (Human)
Gene Symbol
MUC19
UniProt
Additional MUC-19 Products
Product Documents for Human MUC-19 Antibody
Product Specific Notices for Human MUC-19 Antibody
For research use only
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