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Human P-Selectin/CD62P Antibody

R&D Systems, part of Bio-Techne | Catalog # BBA30

R&D Systems, part of Bio-Techne
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BBA30

Key Product Details

Species Reactivity

Validated:

Human

Cited:

Human

Applications

Validated:

Adhesion Blockade, Immunohistochemistry

Cited:

Immunohistochemistry, Immunohistochemistry-Frozen, Neutralization

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # 9E1

Product Specifications

Immunogen

Recombinant human P-Selectin
Extracellular domain

Specificity

This antibody binds to CHO cells transfected with human P-Selectin but not to CHO cells transfected with either human E-Selectin or human L-Selectin.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Endotoxin Level

<0.10 EU per 1 μg of the antibody by the LAL method.

Scientific Data Images for Human P-Selectin/CD62P Antibody

P-Selectin/CD62P antibody in Human Breast Cancer Tissue by Immunohistochemistry (IHC-P).

P-Selectin/CD62P in Human Breast Cancer Tissue.

P-Selectin/CD62P was detected in immersion fixed paraffin-embedded sections of human breast cancer tissue using 25 µg/mL Human P-Selectin/CD62P Monoclonal Antibody (Catalog # BBA30) overnight at 4 °C. Tissue was stained with the Anti-Mouse HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS002) and counterstained with hematoxylin (blue). View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.

Applications for Human P-Selectin/CD62P Antibody

Application
Recommended Usage

Adhesion Blockade

The adhesion of U937 human histiocytic lymphoma cells (5 x 104 cells/well) to immobilized Recombinant Human P-Selectin/CD62P (Catalog # ADP3, 10 µg/mL, 100 µL/well) was maximally inhibited (80-100%) by 1 µg/mL of the antibody.

Immunohistochemistry

8-25 µg/mL
Sample: Immersion fixed paraffin-embedded sections of human breast cancer tissue
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Reviewed Applications

Read 1 review rated 4 using BBA30 in the following applications:

Formulation, Preparation, and Storage

Purification

Protein A or G purified from hybridoma culture supernatant

Reconstitution

Sterile PBS to a final concentration of 0.5 mg/mL.

Reconstitution Buffer Available:
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Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose.

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: P-Selectin/CD62P

P-Selectin, also known as GMP-140 and PADGEM, is a transmembrane glycoprotein expressed by activated platelets and endothelial cells. P-Selectin binds to PSGL-1 on myeloid cells, neutrophils, monocytes, and lymphocytes. P-Selectin plays a role in the adhesion of leukocytes and neutrophils to the endothelium.

Alternate Names

CD62P, GMP140, GRMP, PADGEM, PSEL, SELP

Entrez Gene IDs

6403 (Human); 20344 (Mouse)

Gene Symbol

SELP

Additional P-Selectin/CD62P Products

Product Documents for Human P-Selectin/CD62P Antibody

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Note: Certificate of Analysis not available for kit components.

Product Specific Notices for Human P-Selectin/CD62P Antibody

For research use only

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