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Human p21/CIP1/CDKN1A Biotinylated Antibody

R&D Systems, part of Bio-Techne | Catalog # BAF1047

R&D Systems, part of Bio-Techne
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BAF1047

Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry, Western Blot

Label

Biotin

Antibody Source

Polyclonal Goat IgG

Product Specifications

Immunogen

E. coli-derived recombinant human p21/CIP1/CDKN1A
Ser2-Pro164
Accession # P38936

Specificity

Detects human p21/CIP1/CDKN1A in Western blots.

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for Human p21/CIP1/CDKN1A Biotinylated Antibody

p21/CIP1/CDKN1A in Human Breast.

p21/CIP1/CDKN1A was detected in immersion fixed paraffin-embedded sections of human breast using Goat Anti-Human p21/CIP1/CDKN1A Biotinylated Antigen Affinity-purified Polyclonal Antibody (Catalog # BAF1047) at 5 µg/mL for 1 hour at room temperature followed by incubation with the Anti-Goat IgG VisUCyte™ HRP Polymer Antibody (VC004). Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic (CTS013). Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized to cytoplasm in ductal epithelial cells. Staining was performed using our protocol for IHC Staining with VisUCyte HRP Polymer Detection Reagents.

Applications for Human p21/CIP1/CDKN1A Biotinylated Antibody

Application
Recommended Usage

Immunohistochemistry

5-15 µg/mL
Sample: Immersion fixed paraffin-embedded sections of human breast

Western Blot

0.1 µg/mL
Sample: Recombinant Human p21/CIP1/CDKN1A

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified

Reconstitution

Reconstitute at 0.2 mg/mL in sterile PBS.

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Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: p21/CIP1/CDKN1A

p21CIP1, also called CIP1 (CDK-interacting protein 1) and CDKN1A, is a 21 kDa Cyclin/Cyclin-dependent kinase (Cdk) inhibitor that blocks cell cycle progression from G1 to S phase in the cell cycle. Because p21 is a transcriptional target of the p53 tumor suppressor, p21 expression increases in cells that contain stabilized p53 due to genotoxic stress exposure.

Long Name

p21 Cyclin Dependent Kinase 4 Inhibitor 1A

Alternate Names

CDKN1A, CIP1

Entrez Gene IDs

1026 (Human); 12575 (Mouse); 114851 (Rat)

Gene Symbol

CDKN1A

UniProt

Additional p21/CIP1/CDKN1A Products

Product Documents for Human p21/CIP1/CDKN1A Biotinylated Antibody

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Note: Certificate of Analysis not available for kit components.

Product Specific Notices for Human p21/CIP1/CDKN1A Biotinylated Antibody

For research use only

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