Human Presenilin-1 N-Terminal Fragment Antibody
R&D Systems, part of Bio-Techne | Catalog # MAB1491
Key Product Details
Species Reactivity
Human
Applications
Western Blot
Label
Unconjugated
Antibody Source
Monoclonal Mouse IgG2A Clone # 121130
Product Specifications
Immunogen
E. coli-derived recombinant human Presenilin‑1 N-Terminal Fragment
Met1-Lys80
Accession # P49768
Met1-Lys80
Accession # P49768
Specificity
Detects human Presenilin‑1 N-Terminal Fragment in direct ELISAs and Western blots. In Western blots, no cross-reactivity with recombinant human (rh) Presenilin-1 C-Terminal Fragment, rhPresenilin-2 C-Terminal Fragment, or rhPresenilin-2 N-Terminal Fragment is observed.
Clonality
Monoclonal
Host
Mouse
Isotype
IgG2A
Applications for Human Presenilin-1 N-Terminal Fragment Antibody
Application
Recommended Usage
Western Blot
1 µg/mL
Sample: Recombinant Human Presenilin-1 N-Terminal Fragment
Sample: Recombinant Human Presenilin-1 N-Terminal Fragment
Formulation, Preparation, and Storage
Purification
Protein A or G purified from hybridoma culture supernatant
Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS. For liquid material, refer to CoA for concentration.
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: Presenilin-1
Presenilin‑1 (PS-1) is a 467 amino acid multipass lysosomal membrane protein that is a component of the gamma secretase complex. It is cleaved by endoproteolysis at or near amino acid 298 to generate N‑ and C‑terminal fragments. Some mutations in PS-1 are associated with the risk of early onset familial Alzheimer's disease.
Additional Presenilin-1 Products
Product Documents for Human Presenilin-1 N-Terminal Fragment Antibody
Product Specific Notices for Human Presenilin-1 N-Terminal Fragment Antibody
For research use only
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