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Human RUNX3/CBFA3 Antibody

R&D Systems, part of Bio-Techne | Catalog # AF3765

R&D Systems, part of Bio-Techne
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AF3765
AF3765-SP

Key Product Details

Species Reactivity

Human

Applications

Immunocytochemistry, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG

Product Specifications

Immunogen

E. coli-derived recombinant human RUNX3/CBFA3
Lys186-Tyr415
Accession # Q13761

Specificity

Detects human RUNX3/CBFA3 in direct ELISAs and Western blots. In direct ELISAs and Western blots, this antibody shows less than 1% cross‑reactivity with recombinant human (rh) CBFA1 and rhCBFA2.

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for Human RUNX3/CBFA3 Antibody

RUNX3/CBFA3 antibody in Raji Human Cell Line by Immunocytochemistry (ICC).

RUNX3/CBFA3 in Raji Human Cell Line.

RUNX3/CBFA3 was detected in immersion fixed Raji human Burkitt's lymphoma cell line using Goat Anti-Human RUNX3/CBFA3 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3765) at 15 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (red; Catalog # NL001) and counterstained with DAPI (blue). Specific staining was localized to cytoplasm and nuclei. View our protocol for Fluorescent ICC Staining of Non-adherent Cells.

Applications for Human RUNX3/CBFA3 Antibody

Application
Recommended Usage

Immunocytochemistry

5-15 µg/mL
Sample: Immersion fixed Raji human Burkitt's lymphoma cell line

Western Blot

0.1 µg/mL
Sample: Recombinant Human RUNX3/CBFA3
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified

Reconstitution

Reconstitute at 0.2 mg/mL in sterile PBS. For liquid material, refer to CoA for concentration.

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Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Shipping

Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: RUNX3/CBFA3

RUNX3, also known as CBFA3 and PEBP2 alpha (polyomavirus enhancer binding protein 2 alpha) is a member of the runt-related (RUNX) family of transcription factors. It is the DNA binding subunit of the heterodimeric transcription factor CBF/PEBP2. RUNX3 is a nuclear effector of the BMP/TGF-beta pathways and its inactivation or reduced expression is associated with numerous human malignancies. Two isoforms that differ in their N-terminal 5/19 residues have been reported. The 415 amino acid residue of human RUNX3 shares 91% amino acid sequence homology with mouse or rat RUNX3.

Long Name

Runt-related Transcription Factor 3

Alternate Names

AML2, CBFA3, PEBP2A3, PEBP2AC

Entrez Gene IDs

864 (Human); 12399 (Mouse); 156726 (Rat)

Gene Symbol

RUNX3

UniProt

Additional RUNX3/CBFA3 Products

Product Documents for Human RUNX3/CBFA3 Antibody

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Note: Certificate of Analysis not available for kit components.

Product Specific Notices for Human RUNX3/CBFA3 Antibody

For research use only

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