Human SIRP beta 1/gamma Antibody

R&D Systems, part of Bio-Techne | Catalog # MAB2096

R&D Systems, part of Bio-Techne
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MAB2096
MAB2096-SP
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Key Product Details

Species Reactivity

Human

Applications

CyTOF-ready, Flow Cytometry, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2A Clone # 308906

View all SIRP beta 1/gamma Antibodies »

Product Specifications

Immunogen

Mouse myeloma cell line NS0-derived recombinant human SIRP beta 1
Gly26-Ala369 (Arg53His and Ala363Pro)
Accession # O00241.4

Specificity

Detects human SIRP beta 1 and human SIRP gamma in direct ELISAs and Western blots.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2A

Applications for Human SIRP beta 1/gamma Antibody

Application
Recommended Usage

CyTOF-ready

Ready to be labeled using established conjugation methods. No BSA or other carrier proteins that could interfere with conjugation.

Flow Cytometry

2.5 µg/106 cells
Sample: Human whole blood

Western Blot

1 µg/mL
Sample: Recombinant Human SIRP beta 1 and Recombinant Human SIRP gamma
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified from hybridoma culture supernatant

Reconstitution

Reconstitute at 0.5 mg/mL in sterile PBS. For liquid material, refer to CoA for concentration.

Reconstitution Buffer Available:
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Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Shipping

Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: SIRP beta 1/gamma

SIRP beta1 is a type I transmembrane protein belonging to the SIRP family within the Ig superfamily. Members of this family are characterized by an extracellular region containing a V-set Ig domain containing a J-like sequence and two C1-set Ig domains. Unlike SIRP alpha that has cytoplasmic ITIM domains, SIRP beta1 possesses positively charged residues that allow association with ITAM motif containing adaptor molecules. SIRP beta1 is expressed on cells of monocyte, macrophage or dendritic lineages.

Long Name

Signal-regulatory Protein beta 1/gamma

Alternate Names

CD172 antigen-like family member B, CD172b, signal-regulatory protein beta-1, SIRP-BETA-1

Entrez Gene IDs

10326 (Human)

Gene Symbol

SIRPB1

UniProt

O00241.4

Additional SIRP beta 1/gamma Products

Product Documents for Human SIRP beta 1/gamma Antibody

Product Datasheets

Certificate of Analysis

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Note: Certificate of Analysis not available for kit components.

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Product Specific Notices for Human SIRP beta 1/gamma Antibody

For research use only

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