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Human TAFA2/FAM19A2 Antibody

R&D Systems, part of Bio-Techne | Catalog # MAB4179

R&D Systems, part of Bio-Techne
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MAB4179
MAB4179-SP

Key Product Details

Species Reactivity

Validated:

Human

Cited:

Human

Applications

Validated:

Western Blot

Cited:

Immunohistochemistry

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2B Clone # 447815

Product Specifications

Immunogen

E. coli-derived recombinant human TAFA2/FAM19A2
Ala31-His131
Accession # AAH28403

Specificity

Detects human TAFA2/FAM19A2 in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross‑reactivity with recombinant human TAFA1, 3, 4, or 5 is observed.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2B

Applications for Human TAFA2/FAM19A2 Antibody

Application
Recommended Usage

Western Blot

1 µg/mL
Sample: Recombinant Human TAFA2/FAM19A2 (Catalog # 4179-TA)

Formulation, Preparation, and Storage

Purification

Protein A or G purified from hybridoma culture supernatant

Reconstitution

Reconstitute at 0.5 mg/mL in sterile PBS. For liquid material, refer to CoA for concentration.

Reconstitution Buffer Available:
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Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Shipping

Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: TAFA2/FAM19A2

TAFA2, also called FAM19A2, is a secreted, 11 kDa member of the FAM19/TAFA family of chemokine-like proteins (1). It is synthesized as a 131 amino acid (aa) precursor that contains a 30 aa signal sequence and a 101 aa mature chain . Like other members of the FAM19/TAFA family, with the exception of TAFA5, mature TAFA1 contains 10 regularly spaced cysteine residues that follow the pattern CX7CCX13CXCX14CX11CX4CX5CX10C, where C represents a conserved cysteine residue and X represents any noncysteine amino acid (1). Human TAFA2 shares 97% aa sequence identity with mouse TAFA2 (1). TAFA2 expression can be detected in the central nervous system (CNS), colon, heart, lung, spleen, kidney, and thymus, but its expression in the CNS is 50- to 1000-fold higher than in other tissues (1). Within the CNS, TAFA2 expression is highest in the occipital and frontal cortex (3- to 10-fold more abundantly expressed than in other cortical regions) and medulla (1). Hypotheses for the biological functions of TAFA family members include modulating immune responses in the CNS by functioning as brain-specific chemokines, acting with other chemokines to optimize the recruitment and activity of immune cells in the CNS (1). Alternately, TAFAs may represent a novel class of neurokines that act as regulators of immune nervous cells (1 - 2). Finally, TAFAs may control axonal sprouting following brain injury (1).

References

  1. Tang, Y.T. et al. (2004) Genomics 83:727.
  2. Benveniste, E. (1998) Cytokine Growth Factor Rev. 9:259.

Long Name

Family with Sequence Similarity 19, Member A2

Alternate Names

FAM19A2

Entrez Gene IDs

338811 (Human); 268354 (Mouse)

Gene Symbol

TAFA2

Additional TAFA2/FAM19A2 Products

Product Documents for Human TAFA2/FAM19A2 Antibody

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Note: Certificate of Analysis not available for kit components.

Product Specific Notices for Human TAFA2/FAM19A2 Antibody

For research use only

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