Human TMPRSS9 MAb (Clone 1042526)

R&D Systems, part of Bio-Techne | Catalog # MAB56881

R&D Systems, part of Bio-Techne
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MAB56881-100
MAB56881-SP
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Key Product Details

Species Reactivity

Human

Applications

Flow Cytometry

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # 1042526

View all TMPRSS9 Antibodies »

Product Specifications

Immunogen

E. coli-derived recombinant human TMPRSS9
Glu190-Gln490
Accession # Q7Z410

Specificity

Detects TMPRSS9 in direct Elisa

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Scientific Data Images for Human TMPRSS9 MAb (Clone 1042526)

Detection of Human TMPRSS9 in HEK293 cell line transfected with human TMPRSS9 by Flow Cytometry.

HEK293 cells were transfected with human TMPRSS9 (A) or an irrelevant protein (B), and stained with Mouse Anti-Human TMPRSS9 Monoclonal Antibody (Catalog # MAB56881), followed by staining with Allophycocyanin Anti-Mouse IgG Secondary Antibody (F0101B). Staining was performed using our Staining Membrane-associated Proteins protocol. Mouse IgG1 is the Isotype Control (Not shown; MAB002).

Applications for Human TMPRSS9 MAb (Clone 1042526)

Application
Recommended Usage

Flow Cytometry

25 µg/mL
Sample: HEK293 human embryonic kidney cell line

Formulation, Preparation, and Storage

Purification

Protein A or G purified from hybridoma culture supernatant

Reconstitution

Reconstitute at 0.5 mg/mL in sterile PBS. For liquid material, refer to CoA for concentration.

Reconstitution Buffer Available:
Size / Price
Qty

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Shipping

Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: TMPRSS9

TMPRSS9 (Transmembrane protease, Serine 9; also Polyserine protease 1) is a 116-120 kDa (predicted) member of the TTSP family of membrane-bound serine proteases. It is expressed in fetal tissue, and converts pro-uPA into its active form. Human TMPRSS9 is a 1059 type II transmembrane (TM) protein. It has a 29 aa N-terminal cytoplasmic region and a 1008 aa extracellular domain (ECD) (aa 51-1059). The ECD contains one LDLR region (aa 153-190), followed by three Peptidase S1 domains (aa 203-436, 504-736, and 827-1058), the first two of which are catalytically active. Proteolytic cleavage can generate a soluble 34 kDa Serase 1 (aa 203-503), a 35 kDa Serase 2 (aa 504-826) and an inactive 25 kDa Serase 3 (aa 827-1059). Alternatively, truncated, TM forms of TMPRSS9 such as a 56 kDa TM isotype containing only the Serase 1 domain,  or a 91 kDa (predicted) form containing the Serase 1, 2 and 3 domains may exist. Two potential splice forms are reported. One shows an insertion of 34 aa after Lys90 accompanied by a seven aa substitution for aa 491-1059. A second isoform shows a 34 aa substitution for aa 822-1059. Over aa 190-490, human TMPRSS9 shares 79% aa identity with mouse TMPRSS9.

Long Name

Transmembrane protease, serine 9

Alternate Names

Polyserase-1, Polyserase-I

Entrez Gene IDs

360200 (Human); 432478 (Mouse); 314636 (Rat)

Gene Symbol

TMPRSS9

UniProt

Q7Z410

Additional TMPRSS9 Products

Product Documents for Human TMPRSS9 MAb (Clone 1042526)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Human TMPRSS9 MAb (Clone 1042526)

For research use only

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