Human Transglutaminase 7/TGM7 Biotinylated Antibody
R&D Systems, part of Bio-Techne | Catalog # BAF5426
Key Product Details
Species Reactivity
Human
Applications
Western Blot
Label
Biotin
Antibody Source
Polyclonal Sheep IgG
Product Specifications
Immunogen
S. frugiperda insect ovarian cell line Sf 21-derived recombinant human Transglutaminase 7/TGM7
Asp2-Pro710
Accession # Q96PF1
Asp2-Pro710
Accession # Q96PF1
Specificity
Detects human Transglutaminase 7/TGM7 in Western blots. In Western blots, approximately 5% cross‑reactivity with recombinant human (rh) Transglutaminase 3 is observed, and less than 2% cross-reactivity with rhTransglutaminase 2 and recombinant mouse Transglutaminase 2 is observed.
Clonality
Polyclonal
Host
Sheep
Isotype
IgG
Applications for Human Transglutaminase 7/TGM7 Biotinylated Antibody
Application
Recommended Usage
Western Blot
0.1 µg/mL
Sample: Recombinant Human Transglutaminase 7/TGM7 (Catalog # 5426-TG)
Sample: Recombinant Human Transglutaminase 7/TGM7 (Catalog # 5426-TG)
Please Note: Optimal dilutions of this antibody should be experimentally determined.
Formulation, Preparation, and Storage
Purification
Antigen Affinity-purified
Reconstitution
Reconstitute at 0.2 mg/mL in sterile PBS.
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: Transglutaminase 7/TGM7
Transglutaminase 7 (TG7), encoded by the TGM7 gene, is also known as protein-glutamine-g-glutamyltransferase Z (Tgase Z) (1). It belongs to the family of Transglutaminases that catalyze the posttranslational modification of proteins via calcium dependent cross-linking reactions (2-4). TG7 is ubiquitously expressed in humans (1). Members of the TGM family have been implicated in a variety of human diseases including neurodegenerative diseases, celiac disease, lamellar ichthyosis, bleeding disorders, cataract formation, atherosclerosis, and others (5).
References
- Grenard, P. et al. (2001) J. Biol. Chem. 276:33066.
- Gentile, V. et al. (1991) J. Biol. Chem. 266:478.
- Chen, J.S.K. and Mehta K. (1999) Internat. J. Biochem. Cell Biol. 31:817.
- Griffin, M. et al. (2002) Biochem. J. 368:377.
- Kim, S-Y. et al. (2002) Neurochem. Int. 40:85.
Alternate Names
TGM7, TGMZ, TGZ
Gene Symbol
TGM7
UniProt
Additional Transglutaminase 7/TGM7 Products
Product Documents for Human Transglutaminase 7/TGM7 Biotinylated Antibody
Product Specific Notices for Human Transglutaminase 7/TGM7 Biotinylated Antibody
For research use only
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