Human TrkC PE-conjugated Antibody

R&D Systems, part of Bio-Techne | Catalog # FAB373P

R&D Systems, part of Bio-Techne
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FAB373P
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Key Product Details

Species Reactivity

Validated:

Human

Cited:

Human

Applications

Validated:

Flow Cytometry

Cited:

Flow Cytometry

Label

Phycoerythrin (Excitation = 488 nm, Emission = 565-605 nm)

Antibody Source

Polyclonal Goat IgG

View all TrkC Antibodies »

Product Specifications

Immunogen

Mouse myeloma cell line NS0-derived recombinant human TrkC
Cys32-Asp428
Accession # Q16288

Specificity

Detects human TrkC in direct ELISAs and Western blots. In direct ELISAs and Western blots, less than 1% cross-reactivity with recombinant human TrkB is observed.

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for Human TrkC PE-conjugated Antibody

Detection of TrkC antibody in Differentiated Human Neural Progenitor Cells antibody by Flow Cytometry.

Detection of TrkC in Differentiated Human Neural Progenitor Cells by Flow Cytometry.

Differentiated human neural progenitor cells were stained with Goat Anti-Human TrkC PE-conjugated Antigen Affinity-purified Polyclonal Antibody (Catalog # FAB373P, filled histogram) or isotype control antibody (IC108P, open histogram). View our protocol for Staining Membrane-associated Proteins.

Detection of TrkC in A549 cells by Flow Cytometry

A549 cells were stained with Goat Anti-Human TrkC PE-conjugated Antigen Affinity-purified Polyclonal Antibody (Catalog # FAB373P, filled histogram) or isotype control antibody (Catalog # IC108P, open histogram). View our protocol for Staining Membrane-associated Proteins.

Applications for Human TrkC PE-conjugated Antibody

Application
Recommended Usage

Flow Cytometry

10 µL/106 cells
Sample: Differentiated human neural progenitor cells; A549 human lung carcinoma cell line

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified

Formulation

Supplied in a saline solution containing BSA and Sodium Azide.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store the unopened product at 2 - 8° C. Do not use past expiration date. Protect from light.

Background: TrkC

The neurotrophins, including NGF, BDNF, NT-3 and NT-4/5, constitute a group of structurally related, secreted proteins that play an important role in the development and function of the nervous system. The biological activities of the neurotrophins are mediated by binding to and activating two unrelated receptor types: the p75 neurotrophin receptor (p75NTR) and the Trk family of receptor tyrosine kinases. p75NTR is a member of the tumor necrosis factor receptor superfamily (TNFRSF) and has been designated TNFRSF16. Although it binds all neurotrophins with low-affinity, it complexes with the Trks to form high affinity neurotrophin receptors, and with Sortilin to form high affinity receptors for the proneurotrophins. Three Trk family proteins, TrkA, TrkB and TrkC, that exhibit different ligand specificities have been identified. TrkA binds NGF and NT‑3, TrkB binds BDNF, NT-3 and NT-4/5, and TrkC binds NT-3 and BDNF. All Trk family proteins share a conserved, complex subdomain organization consisting of two cysteine-rich domains, a cluster of three leucine-rich motifs, and two immunoglobulin-like domains in their extracellular region, as well as an intracellular region that contains a tyrosine kinase domain. Natural splice variants of the different Trks, lacking the first cysteine-rich domain, the first and second or all three of the leucine-rich motifs, or the tyrosine kinase domain, have been described. At the protein sequence level, Trks are highly conserved between species with the extracellular domains of human and mouse TrkC showing 94% amino acid sequence identity. The proteins also exhibit cross-species activity. The 135-140 kDa full-length form of TrkC has been found in select embryonic tissues (dorsal root ganglia neurons; renal collecting ducts) and multiple adult cell types, including cortical neurons, astrocytes, endothelial cells, vascular smooth muscle cells, melanocytes, ovarian granulosa cells, and neural stem cells.

Long Name

Neurotrophic Tyrosine Kinase Receptor C

Alternate Names

NTRK3

Entrez Gene IDs

4916 (Human); 18213 (Mouse); 29613 (Rat)

Gene Symbol

NTRK3

UniProt

Q16288

Additional TrkC Products

Product Documents for Human TrkC PE-conjugated Antibody

Product Datasheets

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Product Specific Notices for Human TrkC PE-conjugated Antibody

For research use only

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