Key Product Details

Species Reactivity

Mouse

Applications

CyTOF-ready, Flow Cytometry, T Cell Stimulation

Label

Unconjugated

Antibody Source

Monoclonal Rat IgG2 Clone # AP-MAB0857

Format

Azide and BSA Free

Concentration

1.0 mg/ml

View all ICOS Antibodies »

Product Specifications

Immunogen

Mouse ICOS recombinant protein

Clonality

Monoclonal

Host

Rat

Isotype

IgG2

Applications for ICOS Antibody (AP-MAB0857) - Azide and BSA Free

Application
Recommended Usage

Flow Cytometry

1:10-1:1000
Application Notes
Flow Cytometry, Costimulating T cell activation, proliferation, and humoral immune response. Extremely low level of LPS (< 0.002EU/ug IgG). This antibody is CyTOF ready.

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

PBS

Format

Azide and BSA Free

Preservative

No Preservative

Concentration

1.0 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: ICOS

ICOS, a protein of 47-57kD, is also known as inducible costimulatory molecule and H4. This protein is homologous to the CD28/CTLA-4 proteins. ICOS is expressed on activated T cells and a subset of thymocytes and can costimulate T cells and induce proliferation. In addition ICOS has been shown to be involved in humoral immune responses (B cell germinal center formation). The ICOS ligand, B7h/B7RP-1 and B7-H2 is constitutively expressed in B cell areas of secondary lymphoid organs and can be induced in other tissues by LPS. ICOS stimulation has been shown to potentiate TCR mediated IL-4 and IL-10 production and has been proposed to play a role in Th2 cell development. ICOS stimulation has been shown to be involved in airway tolerance and the downregulation of pulmonary inflammation.

Long Name

Inducible Co-stimulator

Alternate Names

AILIM, CD278, CRP-1

Entrez Gene IDs

54167 (Mouse)

Gene Symbol

ICOS

Additional ICOS Products

Product Documents for ICOS Antibody (AP-MAB0857) - Azide and BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for ICOS Antibody (AP-MAB0857) - Azide and BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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