IFN-alpha/beta R1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-38144

Novus Biologicals, part of Bio-Techne
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NBP2-38144
NBP2-38144-25ul
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Key Product Details

Species Reactivity

Validated:

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all IFN-alpha/beta R1 Antibodies »

Product Summary for IFN-alpha/beta R1 Antibody

Immunogen

This antibody was developed against a recombinant protein corresponding to amino acids: NISTIATVEETNQTDEDHKKYSSQTSQDSGNYSNEDESESKTSEELQQDFV

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for IFN-alpha/beta R1 Antibody

Immunohistochemistry-Paraffin: IFN-alpha/beta R1 Antibody [NBP2-38144]

Immunohistochemistry-Paraffin: IFN-alpha/beta R1 Antibody [NBP2-38144]

Immunohistochemistry-Paraffin: IFN-alpha/beta R1 Antibody [NBP2-38144] - Staining of human cerebral cortex shows weak to moderate cytoplasmic positivity in neurons.
Immunohistochemistry-Paraffin: IFN-alpha/beta R1 Antibody [NBP2-38144]

Immunohistochemistry-Paraffin: IFN-alpha/beta R1 Antibody [NBP2-38144]

Immunohistochemistry-Paraffin: IFN-alpha/beta R1 Antibody [NBP2-38144] - Staining of human tonsil shows strong cytoplasmic positivity in lymphoid cells.
Immunohistochemistry-Paraffin: IFN-alpha/beta R1 Antibody [NBP2-38144]

Immunohistochemistry-Paraffin: IFN-alpha/beta R1 Antibody [NBP2-38144]

Immunohistochemistry-Paraffin: IFN-alpha/beta R1 Antibody [NBP2-38144] - Staining of human small intestine shows strong cytoplasmic positivity in lymphoid cells.

Applications for IFN-alpha/beta R1 Antibody

Application
Recommended Usage

Immunohistochemistry

1:20 - 1:50

Immunohistochemistry-Paraffin

1:20 - 1:50
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: IFN-alpha/beta R1

Interferon alpha receptor 1 (IFN-alpha R1) is a class II cytokine receptor which belongs to type I human interferons (IFNs) family. IFNs plays a role in antiviral, antiproliferative, immunomodulatory, antitumor, and antiparasitic activities by inducing transcription of IFN-stimuated genes (ISGs) through activation of the Jak-STAT pathway. Specifically, IFN- R1 is a 135-kda signal transducing subunit of the IFN alpha/beta receptor complex (IFN-alpha R) (1). IFN-alpha R1 is phospholyated through PTK- and PKC-mediated phosphorylation, which initiates docking of STAT proteins to IFNs. This leads to activation of STAT proteins by PTK-mediated phosphorylation. The mechanism behind the amplification of IFN-alpha R complex mediated transmembrane signaling has been linked to tyrosine phosphorylation on IFN-alpha R1 (2).

Long Name

Interferon alpha/beta Receptor 1

Alternate Names

IFN-aR1, IFN-bR1, IFNAR1, IFNbR1

Gene Symbol

IFNAR1

UniProt

P17181

Additional IFN-alpha/beta R1 Products

Product Documents for IFN-alpha/beta R1 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for IFN-alpha/beta R1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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