IFN-alpha/beta R2 Antibody (117) [CoraFluor™ 1]

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-89446CL1

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Validated:

Human

Applications

ELISA

Label

CoraFluor 1

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # 117

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all IFN-alpha/beta R2 Antibodies »

Product Summary for IFN-alpha/beta R2 Antibody (117) [CoraFluor™ 1]

Immunogen

This antibody was obtained from a rabbit immunized with purified, recombinant Human IFN-alpha/beta R2 (Accession#: NP_997468.1; Met1-Lys243).

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Description

CoraFluor(TM) 1 is a high performance terbium-based TR-FRET (Time-Resolved Fluorescence Resonance Energy Transfer) or TRF (Time-Resolved Fluorescence) donor for high throughput assay development. CoraFluor(IM) 1 absorbs UV light at approximately 340 nm, and emits at approximately 490 nm, 545 nm, 585 nm and 620 nm. It is compatible with common acceptor dyes that absorb at the emission wavelengths of CoraFluor(TM) 1. CoraFluor(TM) 1 can be used for the development of robust and scalable TR-FRET binding assays such as target engagement, ternary complex, protein-protein interaction and protein quantification assays.

Applications for IFN-alpha/beta R2 Antibody (117) [CoraFluor™ 1]

Application
Recommended Usage

ELISA

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS

Preservative

No Preservative

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark. Do not freeze.

Background: IFN-alpha/beta R2

IFNAR2, also known as Interferon alpha/beta receptor 2, has 3 isoforms, an isoform 1 that is 515 amino acid and 58 kDa, an isoform 2 that is 331 amino acid and 37 kDa, and an isoform3 that is 239 amino acid and 27 kDa; expressed in blood cells, lymphoblastoid and fibrosarcoma cell lines, isoform 3 is detected in the urine; is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta, stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. Current research is being performed on several diseases and disorders including interferon, hepatitis c, hepatitis b, multiple sclerosis, measles, hepatocellular carcinoma, liver disease, breast cancer, myeloma, carcinoma, melanoma, adenocarcinoma, respiratory syncytial virus bronchiolitis, portal vein thrombosis, dengue hemorrhagic fever, cervical intraepithelial neoplasia, renal cell carcinoma, hemorrhagic fever, hepatitis c, and japanese encephalitis. This protein has been shown to interact with over 50 proteins including USP18, STAT2, GNB2L1, JAK1, and IFNA13 in cytokine-cytokine receptor interaction, osteoclast differentiation, toll-like receptor signaling pathway, Jak-STAT signaling pathway, natural killer cell mediated cytotoxicity, hepatitis C, measles, THC differentiation pathway, regulation of IFNA signaling and influenza A pathways.

Long Name

Interferon alpha/beta Receptor 2

Alternate Names

IFN-aR2, IFN-bR2, IFNAR2, IFNbR2

Gene Symbol

IFNAR2

Additional IFN-alpha/beta R2 Products

Product Documents for IFN-alpha/beta R2 Antibody (117) [CoraFluor™ 1]

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for IFN-alpha/beta R2 Antibody (117) [CoraFluor™ 1]

CoraFluor (TM) is a trademark of Bio-Techne Corp. Sold for research purposes only under agreement from Massachusetts General Hospital. US patent 2022/0025254

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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