IFN-gamma R1/CD119 Antibody (RM0093-7K23) - Azide and BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-22408

Novus Biologicals, part of Bio-Techne
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NBP1-22408
NBP1-22408-0.025mg
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Key Product Details

Species Reactivity

Validated:

Mouse

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Rat IgG2 Clone # RM0093-7K23

Format

Azide and BSA Free

Concentration

LYOPH mg/ml

View all IFN-gamma R1/CD119 Antibodies »

Product Summary for IFN-gamma R1/CD119 Antibody (RM0093-7K23) - Azide and BSA Free

Immunogen

Mouse recombinant IFN-gamma R1/CD119

Clonality

Monoclonal

Host

Rat

Isotype

IgG2

Scientific Data Images for IFN-gamma R1/CD119 Antibody (RM0093-7K23) - Azide and BSA Free

Immunohistochemistry-Paraffin: IFN-gamma R1/CD119 Antibody (RM0093-7K23) - Azide and BSA Free [NBP1-22408]

Immunohistochemistry-Paraffin: IFN-gamma R1/CD119 Antibody (RM0093-7K23) - Azide and BSA Free [NBP1-22408]

Immunohistochemistry-Paraffin: IFN-gamma R1/CD119 Antibody (RM0093-7K23) [NBP1-22408] - The Kidney tissue samples from the Folic Acid induced kidney injury model were fixed using 4% PFA at 4C for overnight and embeded in paraffin. 4um section was sublected to IHC with NBP1-22408

Applications for IFN-gamma R1/CD119 Antibody (RM0093-7K23) - Azide and BSA Free

Application
Recommended Usage

Western Blot

1:500-1:1000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Reconstitution

Reconstitute with sterilized PBS to a final concentration of 0.5 mg/ml.

Formulation

Lyophilized from a 0.2 um filtered solution in PBS. 0.025 mg size is provided in liquid form, PBS

Format

Azide and BSA Free

Preservative

No Preservative

Concentration

LYOPH mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: IFN-gamma R1/CD119

The IFNG receptor complex is composed of two type I membrane proteins, IFNGR1 (IFNGR alpha) and IFNGR2 (IFNGR beta). Both receptor proteins are members of the type II cytokine receptor family and share 52% overall sequence identity. The IFNG receptor is constitutively expressed in most cell types. Soluble IFNG has been detected in biological fluids. IFNGR1 is required for ligand-binding and signaling. It binds to IFNG with high affinity and is a potent IFNG antagonist. In signal transduction, IFNG induces tyrosine phosphorylation of IFNGR1 leading to the formation of a docking site on the activated receptor for Stat1, which specifically activates IFNG-induced gene transcription. Human IFNGR1, a 227 amino acid residue protein, has a calculated molecular mass of approximately 25 kDa. As a result of glycosylation, the recombinant IFNGR1 migrates as a 40 to 50 kDa protein in SDS-PAGE. Human and mouse IFNGRI share approximately 52% amino acid sequence identity and each interacts with IFNG in a strictly species-specific manner.

Long Name

Interferon gamma Receptor 1

Alternate Names

CD119, IFN-gR1, IFNgammaR1, IFNGR1

Entrez Gene IDs

3459 (Human)

Gene Symbol

IFNGR1

Additional IFN-gamma R1/CD119 Products

Product Documents for IFN-gamma R1/CD119 Antibody (RM0093-7K23) - Azide and BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for IFN-gamma R1/CD119 Antibody (RM0093-7K23) - Azide and BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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