IGF-I R/IGF1R Antibody (S07-7E1)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-14897

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-14897-100ul
NBP3-14897-25ul
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Key Product Details

Species Reactivity

Validated:

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # S07-7E1

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all IGF-I R/IGF1R Antibodies »

Product Summary for IGF-I R/IGF1R Antibody (S07-7E1)

Immunogen

Recombinant protein of human IGF-I R/IGF1R (Uniprot#: P08069)

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

95 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for IGF-I R/IGF1R Antibody (S07-7E1)

Western Blot: IGF-I R/IGF1R Antibody (S07-7E1) [NBP3-14897]

Western Blot: IGF-I R/IGF1R Antibody (S07-7E1) [NBP3-14897]

Western Blot: IGF-I R/IGF1R Antibody (S07-7E1) [NBP3-14897] - Western blot detection of IGF-I R/IGF1R in Hela, A549, HL-60, U2OS cell lysates using IGF-I R/IGF1R Rabbit mAb (1:1000 diluted). Predicted band size: 155kDa. Observed band size: 95kDa.
Immunohistochemistry: IGF-I R/IGF1R Antibody (S07-7E1) [NBP3-14897]

Immunohistochemistry: IGF-I R/IGF1R Antibody (S07-7E1) [NBP3-14897]

Immunohistochemistry: IGF-I R/IGF1R Antibody (S07-7E1) [NBP3-14897] - Immunohistochemical of IGF-I R/IGF1R in Human lung cancer tissue using IGF-I R/IGF1R antibody at dilution 1/50

Applications for IGF-I R/IGF1R Antibody (S07-7E1)

Application
Recommended Usage

Immunohistochemistry

1/50

Western Blot

1/1000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40% Glycerol, 0.05% BSA

Preservative

0.01% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: IGF-I R/IGF1R

The IGF1 receptor prefers IGF1 over IGF2 and weakly binds insulin. IGF1 receptor is a disulfide-linked heterotetrameric transmembrane protein consisting of two alpha (130 kD) and two beta (95 kD) subunits. Both the alpha and beta subunits are encoded within a single receptor precursor cDNA. The IGF1 receptor is therefore similar in structure to the insulin receptor. The proreceptor polypeptide is proteolytically cleaved and disulfide-linked to yield the mature heterotetrameric receptor. The IGF1 receptor is highly expressed in all cell types and tissues and is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival

Long Name

Insulin-like Growth Factor I Receptor

Alternate Names

CD221, IGF-1R, IGF-IR, IGF1R, IGFIR

Gene Symbol

IGF1R

Additional IGF-I R/IGF1R Products

Product Documents for IGF-I R/IGF1R Antibody (S07-7E1)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for IGF-I R/IGF1R Antibody (S07-7E1)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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