IGF-I R/IGF1R Products
IGF-I R/IGF1R (Insulin-like Growth Factor I Receptor), also known as CD221, is a ubiquitously expressed heterotetrameric transmembrane glycoprotein consisting of two alpha and two beta subunits. It binds IGF-1 with high affinity, IGF2 with lower affinity, and Insulin with lowest affinity. IGF1R/Insulin R hybrids respond primarily to IGF-1 and may downregulate cellular responses to Insulin. IGF signaling is also modulated by IGF binding proteins and the scavenger receptor, IGF-II R/IGF2R. Mice lacking IGF1R show intrauterine growth deficiency and die at birth due to respiratory failure, and IGF1R mutations in humans can retarded pre- and postnatal growth. IGF-1 and its receptor are particularly important for neurogenesis, with deficiency producing microcephaly and learning disorders. IGF1R expression on human embryonic stem cells is important for their survival and clonogenicity.
Products:
503 results for "IGF-I R/IGF1R" in Products
503 results for "IGF-I R/IGF1R" in Products
IGF-I R/IGF1R Products
IGF-I R/IGF1R (Insulin-like Growth Factor I Receptor), also known as CD221, is a ubiquitously expressed heterotetrameric transmembrane glycoprotein consisting of two alpha and two beta subunits. It binds IGF-1 with high affinity, IGF2 with lower affinity, and Insulin with lowest affinity. IGF1R/Insulin R hybrids respond primarily to IGF-1 and may downregulate cellular responses to Insulin. IGF signaling is also modulated by IGF binding proteins and the scavenger receptor, IGF-II R/IGF2R. Mice lacking IGF1R show intrauterine growth deficiency and die at birth due to respiratory failure, and IGF1R mutations in humans can retarded pre- and postnatal growth. IGF-1 and its receptor are particularly important for neurogenesis, with deficiency producing microcephaly and learning disorders. IGF1R expression on human embryonic stem cells is important for their survival and clonogenicity.
Products:
Reactivity: | Human, Mouse |
Details: | Mouse IgG1 Monoclonal Clone #33255 |
Applications: | WB, Flow, IHC, ICC, Neut |
Reactivity: | Human, Mouse |
Details: | Goat IgG Polyclonal |
Applications: | WB, IHC, ICC, Neut |
Reactivity: | Human |
Details: | Mouse IgG2c Kappa Monoclonal Clone #IGF1R/4667 |
Applications: | IHC, ICC/IF, Flow, Func, MA |
Source: | NS0 |
Accession #: | P08069 |
Applications: | Bind |
Reactivity: | Human |
Details: | Mouse IgG2A Monoclonal Clone #3G5C1 |
Applications: | IHC, WB, ELISA |
Analyzed by SEC-MALS
Source: | NS0 |
Accession #: | P08069 |
Applications: | Bind |
Applications: | ELISA |
Reactivity: | Human, Mouse, Rat, Primate, Equine |
Details: | Rabbit IgG Polyclonal |
Applications: | IHC, WB, ICC/IF |
Reactivity: | Human |
Details: | Mouse IgG2c Kappa Monoclonal Clone #IGF1R/4667 |
Applications: | ICC/IF, Flow, MA |
Reactivity: | Human |
Details: | Mouse IgG2c Kappa Monoclonal Clone #IGF1R/4667 |
Applications: | ICC/IF, Flow, MA |
Reactivity: | Human |
Details: | Mouse IgG2c Kappa Monoclonal Clone #IGF1R/4667 |
Applications: | ICC/IF, Flow, MA |
Reactivity: | Human |
Details: | Mouse IgG2c Kappa Monoclonal Clone #IGF1R/4667 |
Applications: | ICC/IF, Flow, MA |
Reactivity: | Human |
Details: | Mouse IgG2c Kappa Monoclonal Clone #IGF1R/4667 |
Applications: | ICC/IF, Flow, MA |
Reactivity: | Human |
Details: | Mouse IgG1 Monoclonal Clone #33255 |
Applications: | Flow |
Reactivity: | Human, Mouse, Rat, Primate |
Details: | Rabbit IgG Polyclonal |
Applications: | IHC, WB, ICC/IF, Simple Western |
Source: | CHO |
Accession #: | Q60751 |
Applications: | BA |
Reactivity: | Human |
Details: | Mouse IgG Monoclonal Clone #33255 |
Applications: | Flow |
Assay Range: | 250 - 16,000 pg/mL |
Applications: | ELISA |
Recombinant Monoclonal Antibody For Research Use Only
Reactivity: | Human |
Details: | Human IgG1 Monoclonal Clone #Hu14F2 |
Applications: | Flow |
Reactivity: | Human |
Details: | Mouse IgG1 Monoclonal Clone #1H7 |
Applications: | IHC, WB, Flow |
Recombinant Monoclonal Antibody
Reactivity: | Human, Mouse, Rat |
Details: | Rabbit IgG Monoclonal Clone #HL1957 |
Applications: | IHC, WB, ICC/IF |
Reactivity: | Human |
Details: | Goat IgG Polyclonal |
Applications: | WB |
Reactivity: | Human |
Details: | Mouse IgG1 Monoclonal Clone #33255 |
Applications: | Flow |
Reactivity: | Human |
Details: | Mouse IgG1 Monoclonal Clone #33255 |
Applications: | Flow |
Assay Range: | 156 - 10,000 pg/mL |
Applications: | ELISA |