IL-10R alpha Antibody (OTI1D10)

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-46049

Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # OTI1D10

Concentration

1 mg/ml

View all IL-10 R alpha Antibodies »

Product Specifications

Immunogen

Full length human recombinant protein of human IL10RA(NP_001549) produced in HEK293T cell.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Theoretical MW

60.8 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for IL-10R alpha Antibody (OTI1D10)

Western Blot: IL-10R alpha Antibody (OTI1D10) [NBP2-46049]

Western Blot: IL-10R alpha Antibody (OTI1D10) [NBP2-46049]

Western Blot: IL-10 R alpha Antibody (1D10) [NBP2-46049] - Analysis of HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY IL-10 R alpha.
Immunohistochemistry-Paraffin: IL-10R alpha Antibody (OTI1D10) [NBP2-46049]

Immunohistochemistry-Paraffin: IL-10R alpha Antibody (OTI1D10) [NBP2-46049]

Immunohistochemistry-Paraffin: IL-10R alpha Antibody (OTI1D10) [NBP2-46049] - Adult human kidney tissue section stained with IL-10R alpha Antibody (OTI1D10). IHC-P image submitted by a verified customer review.
Immunohistochemistry: IL-10R alpha Antibody (OTI1D10) [NBP2-46049]

Immunohistochemistry: IL-10R alpha Antibody (OTI1D10) [NBP2-46049]

Immunohistochemistry: IL-10 R alpha Antibody (1D10) [NBP2-46049] - Analysis of Human endometrium tissue. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min)
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Applications for IL-10R alpha Antibody (OTI1D10)

Application
Recommended Usage

Immunohistochemistry

1:150

Western Blot

1:4000

Reviewed Applications

Read 1 review rated 5 using NBP2-46049 in the following applications:

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.3), 1.0% BSA, 50% Glycerol

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: IL-10 R alpha

The IL-10 receptor, IL-10R, is a member of the class II subgroup of the cytokine receptor family and exhibits structural similarity to the interferon receptor. IL-10R is expressed in B cells and T helper cells, as well as in LPS-induced mouse fibroblasts. Overall, mouse IL-10R and human IL-10R share 60% sequence identity at the protein level. Stimulation with IL-10 leads to tyrosine phosphorylation of JAK1 and Tyk2, but not JAK2 or JAK3. In addition to its role as an antagonist of IFN-gamma-mediated macrophage activation, IL-10Ralpha transmits differentiation as well as proliferative signals. IL-10R is constitutively expressed on human natural killer (NK) cells and the direct binding of IL-10 potentiates cytokine production by human NK cells.

Long Name

Interleukin 10 Receptor alpha

Alternate Names

CDw210a, IL-10Ra, IL10R alpha, IL10RA

Gene Symbol

IL10RA

Additional IL-10 R alpha Products

Product Documents for IL-10R alpha Antibody (OTI1D10)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for IL-10R alpha Antibody (OTI1D10)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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