IL-12 R beta 1 Antibody (MM0363-7V24) - Azide and BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-11659

Novus Biologicals, part of Bio-Techne
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NBP2-11659
NBP2-11659-0.025mg
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Key Product Details

Species Reactivity

Human

Applications

CyTOF-ready, Flow Cytometry

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # MM0363-7V24

Format

Azide and BSA Free

Concentration

LYOPH mg/ml

View all IL-12 R beta 1 Antibodies »

Product Specifications

Immunogen

Human recombinant IL-12 R beta 1 (extracellular domain)

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Scientific Data Images for IL-12 R beta 1 Antibody (MM0363-7V24) - Azide and BSA Free

Immunohistochemistry: IL-12 R beta 1 Antibody (MM0363-7V24) [NBP2-11659]

Applications for IL-12 R beta 1 Antibody (MM0363-7V24) - Azide and BSA Free

Application
Recommended Usage

Flow Cytometry

1:50-1:200
Application Notes
This antibody is Cytof ready.

Formulation, Preparation, and Storage

Purification

Protein G purified

Reconstitution

Reconstitute with sterilized PBS to a final concentration of 0.5 mg/ml.

Formulation

Lyophilized from a 0.2 um filtered solution in PBS. 0.025 mg size is provided in liquid form, PBS

Format

Azide and BSA Free

Preservative

No Preservative

Concentration

LYOPH mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: IL-12 R beta 1

IL12RB1, also known as Interleukin-12 receptor subunit beta-1, has 3 isoforms, an isoform 1 that is 662 amino acid and 73 kDa, an isoform 2 that is 660 amino acid and 73 kDa, and an isoform3 that is 381 amino acid and 42 kDa; acts as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction; forms a functional, high affinity receptor for IL12 when combined with IL12RB2, and associates also with IL23R to form the interleukin-23 receptor which plays a role in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade. Current research is being pursued on this protein involvement in several diseases and disorders including immunodeficiency, mycobacterial and salmonella infections, salmonella gastroenteritis, mycobacterium infectious disease, myocarditis, lupus erythematosus, tuberculosis, sarcoidosis, neurological disorder, rheumatoid arthritis, gastroenteritis, asthma, and dermatitis. IL12RB1 protein involvement has been observed with relation to IL23R, IL23A, IL12A, IL12B, and IL12RB2 in the immune response IL-12 signaling pathway, immune response IL-22 signaling pathway, immune response IL-12-induced IFN-gamma production, cytokine production by Th17 cells in CF, and Jak-STAT signaling pathway.

Long Name

Interleukin 12 Receptor beta 1

Alternate Names

CD212, IL-12Rb1, IL12R beta 1, IL12RB1

Gene Symbol

IL12RB1

UniProt

P42701

Additional IL-12 R beta 1 Products

Product Documents for IL-12 R beta 1 Antibody (MM0363-7V24) - Azide and BSA Free

Product Datasheets

Certificate of Analysis

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Product Specific Notices for IL-12 R beta 1 Antibody (MM0363-7V24) - Azide and BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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