IL-18 BPa/IL18BP Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-38481

Novus Biologicals, part of Bio-Techne
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NBP2-38481-25ul
NBP2-38481
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Key Product Details

Validated by

Orthogonal Validation

Species Reactivity

Validated:

Human

Cited:

Human

Applications

Validated:

Immunohistochemistry, Immunohistochemistry-Paraffin

Cited:

IF/IHC

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all IL-18 BPa Antibodies »

Product Specifications

Immunogen

This antibody was developed against a recombinant protein corresponding to amino acids: RLWEGSTSRERGSTGTQLCKALVLEQLTPALHSTNFSCVLVDPEQVVQRHVVLAQLWAGLRATLPPTQEALPSSHSSPQQQG

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for IL-18 BPa/IL18BP Antibody

Immunohistochemistry-Paraffin: IL-18 BPa/IL18BP Antibody [NBP2-38481]

Immunohistochemistry-Paraffin: IL-18 BPa/IL18BP Antibody [NBP2-38481]

Immunohistochemistry-Paraffin: IL-18 BPa/IL18BP Antibody [NBP2-38481] - Staining in human lymph node and pancreas tissues using anti-IL18BP antibody. Corresponding IL18BP RNA-seq data are presented for the same tissues.
Immunohistochemistry-Paraffin: IL-18 BPa/IL18BP Antibody [NBP2-38481]

Immunohistochemistry-Paraffin: IL-18 BPa/IL18BP Antibody [NBP2-38481]

Immunohistochemistry-Paraffin: IL-18 BPa/IL18BP Antibody [NBP2-38481] - Staining of human pancreas shows low expression as expected.
Immunohistochemistry-Paraffin: IL-18 BPa/IL18BP Antibody [NBP2-38481]

Immunohistochemistry-Paraffin: IL-18 BPa/IL18BP Antibody [NBP2-38481]

Immunohistochemistry-Paraffin: IL-18 BPa/IL18BP Antibody [NBP2-38481] - Staining of human lymph node shows high expression.

Applications for IL-18 BPa/IL18BP Antibody

Application
Recommended Usage

Immunohistochemistry

1:500 - 1:1000

Immunohistochemistry-Paraffin

1:500 - 1:1000
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: IL-18 BPa

IL-18BP which binds to IL-18, also known as interferon-gamma inducing factor (IGIF) which is a pro-inflammatory cytokine that belongs to the IL-1 family (1). IL-18 is a pleiotropic factor involved in the regulation of both innate and acquired immune responses, playing a key role in autoimmune, inflammatory, and infectious diseases (2). Interleukin-18 binding protein (IL18-BP) is an inhibitor of the pro-inflammatory cytokine IL18. The recombinant forms of IL18BP did not exhibit species specificity and prevented interleukin-18 binding to its receptor. In addition, they inhibited interleukine-18 dependent IFN-gamma production from KG-1 cells effectively. These results suggest that the interleukin-18 binding protein may possess interleukine-18 antagonist activity (3). IL-18 plays an important role in host defense against microbial pathogens. Many poxviruses encode homologous IL-18BP that neutralizes IL-18 activity. Data show that IL-18BP prevents IL-18 from binding to IL-18R by interacting with three residues that are part of the binding site for IL-18Ralpha (4).

Long Name

Interleukin 18 Binding Protein Isoform a

Alternate Names

IL18 BPa, IL18BP

Gene Symbol

IL18BP

UniProt

O95998

Additional IL-18 BPa Products

Product Documents for IL-18 BPa/IL18BP Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for IL-18 BPa/IL18BP Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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