IL-23R Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB600-1147

Novus Biologicals, part of Bio-Techne
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NB600-1147-0.2ml
NB600-1147SS
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Key Product Details

Species Reactivity

Validated:

Human, Mouse

Cited:

Human, Mouse

Applications

Validated:

Flow (Cell Surface), Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Paraffin, Simple Western, Western Blot

Cited:

Flow (Cell Surface), IF/IHC, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

1.0 mg/ml

View all IL-23R Antibodies »

Product Specifications

Immunogen

Synthetic peptide located at amino acids 439-455 (EIFIPEHKPTDYKKENT) of human IL-23R (NP_653302).

Localization

Cell Membrane

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

72 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for IL-23R Antibody

Western Blot: IL-23R Antibody [NB600-1147]

Western Blot: IL-23R Antibody [NB600-1147]

Western Blot: IL-23 R Antibody [NB600-1147] - Analysis of IL-23R in (A) Jurkat and (B) NIH 3T3 cells. 1:500 dilution.
Immunohistochemistry-Paraffin: IL-23R Antibody [NB600-1147]

Immunohistochemistry-Paraffin: IL-23R Antibody [NB600-1147]

Immunohistochemistry-Paraffin: IL-23 R Antibody [NB600-1147] - Staining of IL-23 Receptor in Human periarterial lymphatic sheath lymphocytes (spleen) at 10 ug/ml. Hematoxylin-eosin counterstain.
Western Blot: IL-23R Antibody [NB600-1147]

Western Blot: IL-23R Antibody [NB600-1147]

Western Blot: IL-23 R Antibody [NB600-1147] - Analysis using IL-23R antibody. Lysate from (A) human Jurkat and (B) Mouse NIH 3T3 cells probed with IL-23R antibody at 0.5 ug/ml.
View 2 more images

Applications for IL-23R Antibody

Application
Recommended Usage

Flow (Cell Surface)

reported in scientific literature (PMID 24358364)

Flow Cytometry

1:10-1:1000

Immunohistochemistry

5-10 ug/ml

Immunohistochemistry-Paraffin

5-10 ug/ml

Simple Western

1:10

Western Blot

0.5-1.0 ug/ml
Application Notes
Based on immunogen sequence, this antibody will recognize the 629 amino acid (approx. 68 KDa) , 390 AA (approx. 42 KDa) and 227 AA (approx. 26 KDa) forms of human IL-23R. Flow (Cell Surface): See Kortylweski et al, 2009 for details.

In Simple Western only 10 - 15 uL of the recommended dilution is used per data point. Separated by Size-Wes, Sally Sue/Peggy Sue.

Reviewed Applications

Read 1 review rated 4 using NB600-1147 in the following applications:

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

PBS

Preservative

0.05% Sodium Azide

Concentration

1.0 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: IL-23R

IL-23 is a heterodimeric cytokine that shares biological properties with proinflammatory cytokines. IL-23 is composed of the IL-12p40 soluble receptor subunit and a novel cytokine-like subunit related to IL-12p35, termed p19. IL-23 mediates it cellular function by binding to IL-23R, which pairs with IL-12Rb1 to confer IL-23 responsiveness. However, human IL-12 does not bind to human IL-23R. IL-23 has been shown to possess biological activities on T cells that are similar as well distinct from those of IL-12.

Long Name

Interleukin 23 Receptor

Alternate Names

IL-23 R, IL23R

Entrez Gene IDs

149233 (Human); 209590 (Mouse)

Gene Symbol

IL23R

UniProt

Q5VWK5

Additional IL-23R Products

Product Documents for IL-23R Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for IL-23R Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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