IL-34 Antibody (C6)
Novus Biologicals, part of Bio-Techne | Catalog # NBP3-41879
Key Product Details
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Scientific Data Images for IL-34 Antibody (C6)
Western Blot: IL-34 Antibody (C6) [NBP3-41879] -
Western Blot: IL-34 Antibody (C6) [NBP3-41879] - Sample: Lane1: Rat Spleen lysate; Lane2: Rat Cerebrum lysate; Lane3: Rat Skin lysate; Lane4: HepG2 cell lysate; Lane5: A431 cell lysate Primary Ab: 0.4ug/ml NBP3-41879; Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Mouse IgG Polyclonal AntibodyApplications for IL-34 Antibody (C6)
Immunocytochemistry/ Immunofluorescence
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Western Blot
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Background: IL-34
Interleukin 34 (IL-34; also known as uncharacterized protein C16orf77) is secreted as a homodimer consisting of 39 kDa monomers. It belongs to no known cytokine family. Human IL-34 is synthesized as a 242 amino acid (aa) precursor that contains a 20 aa signal sequence and a 222 aa mature chain. The mature chain contains one potential site of N-linked glycosylation. Human IL-34 is 71% identical to mouse IL-34 on the amino acid level.
IL-34 is expressed in various tissues, including the heart, brain, liver, kidney, spleen, thymus, testes, ovary, small intestine, prostate, and colon, and is most abundant in the spleen . The receptor for IL-34 is colony-stimulating factor 1 receptor (CSF-1R). IL-34 stimulates monocyte proliferation. In functional studies, IL-34, like CSF-1, the other ligand for CSF-1R, stimulated phosphorylation of extracellular signal-regulated kinase-1 and -2 (ERK1/2) in human monocytes. In addition, IL-34 promoted the formation of the colony-forming unit-macrophage (CFU-M), a macrophage progenitor, in human bone marrow cultures.
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Additional IL-34 Products
Product Specific Notices for IL-34 Antibody (C6)
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.