Insulin Antibody (D6C4cc)

Novus Biologicals, part of Bio-Techne | Catalog # NB120-8304

Novus Biologicals, part of Bio-Techne
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NB120-8304
NB120-8304-0.05mg
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Key Product Details

Species Reactivity

Human, Mouse, Rat, Porcine, Bovine

Applications

Immunohistochemistry, Immunohistochemistry-Frozen, Sandwich ELISA

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 kappa Clone # D6C4cc

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Insulin Antibodies »

Product Specifications

Immunogen

Hybridoma clone has been derived from hybridization of Sp2/0 myeloma cells with spleen cells of Balb/c mice immunized with native human insulin.

Specificity

This is specific for insulin and proinsulin. Cross-reacts with human, bovine and porcine insulin and proinsulin.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1 kappa

Applications for Insulin Antibody (D6C4cc)

Application
Recommended Usage

Immunohistochemistry

1:10-1:500

Immunohistochemistry-Frozen

1:10-1:500

Sandwich ELISA

1:100-1:2000
Application Notes
Kd for D6C4 is 8.1 x 10^-8 M. Detection of rat-mouse insulin/proinsulin in two-site enzyme immunoassay. Recommend pair (capture-detection): NB120-8304 - NB200-435.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS (pH 7.4)

Preservative

0.09% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C. Do not freeze.

Background: Insulin

Insulin is one of the major regulatory hormones of intermediate metabolism throughout the body. The biological actions of this hormone involve integration of carbohydrate, protein, and lipid metabolism. Insulin enhances membrane transport of glucose, amino acids, and certain ions. It also promotes glycogen storage, formation of triglycerides and synthesis of proteins and nucleic acids. Immunocytochemical investigations have localized insulin in the B cells of pancreatic islets of Langerhans. Deficiency of insulin results in diabetes mellitus, one of the leading causes of morbidity and mortality in the general population. Insulin is also present in tumors of B cell origin such as insulinoma.

Alternate Names

IDDM2, ILPR, INS, IRDN, MODY10

Entrez Gene IDs

24505 (Rat)

Gene Symbol

INS

Additional Insulin Products

Product Documents for Insulin Antibody (D6C4cc)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for Insulin Antibody (D6C4cc)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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