Integrin alpha 2/CD49b Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-38995

Novus Biologicals, part of Bio-Techne
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NBP2-38995
NBP2-38995-25ul
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Key Product Details

Validated by

Orthogonal Validation, Independent Antibodies

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Integrin alpha 2/CD49b Antibodies »

Product Specifications

Immunogen

This antibody was developed against a recombinant protein corresponding to amino acids: ALEAYSETAKVFSIPFHKDCGEDGLCISDLVLDVRQIPAAQEQPFIVSNQNKRLTFSVTLKNKRESAYNTGIVVDFSENLFFASFSLPV

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: Rat (80%)

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Integrin alpha 2/CD49b Antibody

Immunohistochemistry-Paraffin: Integrin alpha 2/CD49b Antibody [NBP2-38995]

Immunohistochemistry-Paraffin: Integrin alpha 2/CD49b Antibody [NBP2-38995]

Immunohistochemistry-Paraffin: Integrin alpha 2/CD49b Antibody [NBP2-38995] - Analysis in human skin and liver tissues. Corresponding ITGA2 RNA-seq data are presented for the same tissues.
Immunohistochemistry-Paraffin: Integrin alpha 2/CD49b Antibody [NBP2-38995]

Immunohistochemistry-Paraffin: Integrin alpha 2/CD49b Antibody [NBP2-38995]

Immunohistochemistry-Paraffin: Integrin alpha 2/CD49b Antibody [NBP2-38995] - Staining of human endometrium, rectum, skin and urinary bladder using Anti-ITGA2 antibody NBP2-38995 (A) shows similar protein distribution across tissues to independent antibody NBP2-38902 (B).
Western Blot: Integrin alpha 2/CD49b Antibody [NBP2-38995]

Western Blot: Integrin alpha 2/CD49b Antibody [NBP2-38995]

Western Blot: Integrin alpha 2/CD49b Antibody [NBP2-38995] - Analysis in human cell lines A-431 and HeLa. Corresponding RNA-seq data are presented for the same cell lines. Loading control: Anti-PPIB.
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Applications for Integrin alpha 2/CD49b Antibody

Application
Recommended Usage

Immunohistochemistry

1:20 - 1:50

Immunohistochemistry-Paraffin

1:20 - 1:50

Western Blot

0.04-0.4 ug/ml
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Integrin alpha 2/CD49b

Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. They are responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells.

Alternate Names

CD49b, ITGA2, VLA-2 alpha

Gene Symbol

ITGA2

UniProt

P17301

Additional Integrin alpha 2/CD49b Products

Product Documents for Integrin alpha 2/CD49b Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Integrin alpha 2/CD49b Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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