Integrin alpha 2b/CD41 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-84581

Novus Biologicals, part of Bio-Techne
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NBP1-84581
NBP1-84581-25ul
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Key Product Details

Validated by

Orthogonal Validation, Independent Antibodies

Species Reactivity

Human

Applications

Validated:

Immunohistochemistry, Immunohistochemistry-Paraffin, Simple Western

Cited:

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Integrin alpha 2b/CD41 Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: GATGHNIPQKLSLNAELQLDRQKPRQGRRVLLLGSQQAGTTLNLDLGGKHSPICHTTMAFLRDEADFRDKLSPIVLSLNVSLPPTEAGMAPAV

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: Mouse (85%), Rat (82%)

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Integrin alpha 2b/CD41 Antibody

Immunohistochemistry-Paraffin: Integrin alpha 2b/CD41 Antibody [NBP1-84581]

Immunohistochemistry-Paraffin: Integrin alpha 2b/CD41 Antibody [NBP1-84581]

Immunohistochemistry-Paraffin: Integrin alpha 2b/CD41 Antibody [NBP1-84581] - Analysis in human bone marrow and colon tissues. Corresponding Integrin alpha 2b/CD41 RNA-seq data are presented for the same tissues.
Immunohistochemistry-Paraffin: Integrin alpha 2b/CD41 Antibody [NBP1-84581]

Immunohistochemistry-Paraffin: Integrin alpha 2b/CD41 Antibody [NBP1-84581]

Immunohistochemistry-Paraffin: Integrin alpha 2b/CD41 Antibody [NBP1-84581] - Staining of human bone marrow, colon, liver and lymph node using Anti-ITGA2B antibody NBP1-84581 (A) shows similar protein distribution across tissues to independent antibody NBP1-84579 (B).
Immunohistochemistry-Paraffin: Integrin alpha 2b/CD41 Antibody [NBP1-84581]

Immunohistochemistry-Paraffin: Integrin alpha 2b/CD41 Antibody [NBP1-84581]

Immunohistochemistry-Paraffin: Integrin alpha 2b/CD41 Antibody [NBP1-84581] - Staining of human lymph node shows no positivity in non-germinal center cells as expected.
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Applications for Integrin alpha 2b/CD41 Antibody

Application
Recommended Usage

Immunohistochemistry

1:2500 - 1:5000

Immunohistochemistry-Paraffin

1:2500 - 1:5000

Simple Western

1:25
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended. In Simple Western only 10-15 uL of the recommended dilution is used per data point.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Integrin alpha 2b/CD41

Integrin alpha 2b (CD41) is a calcium-dependent, noncovalently associated heterodimer and contains a heavy chain (GPIIb alpha) and a light chain (GPIIb beta) linked by a single disulfide bond. The Integrin alpha 2B chain interacts with the Integrin beta 3 subunit/CD61 to form the platelet glycoprotein complex, gpIIb/IIIa. It is expressed on platelets and megakaryocytes. Ligands for the gpIIb/IIIa heterodimer include fibrinogen, von Willebrand factor, fibronectin, vitronectin, and thrombospondin. The gpIIb/IIIa complex is the major Integrin on platelets and is important for platelet adhesion and aggregation.

Alternate Names

CD41, GP2B, GPIIb, GTA, HPA3, ITGA2b

Gene Symbol

ITGA2B

Additional Integrin alpha 2b/CD41 Products

Product Documents for Integrin alpha 2b/CD41 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Integrin alpha 2b/CD41 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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