Integrin alpha 4/CD49d Antibody - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NB110-55525

Novus Biologicals, part of Bio-Techne
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NB110-55525
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat, Porcine, Bat, Canine, Hamster, Monkey, Primate, Rabbit

Cited:

Human

Predicted:

Bovine (94%), Equine (94%), Opossum (94%). Backed by our 100% Guarantee.

Applications

Validated:

Immunohistochemistry, Immunohistochemistry-Paraffin

Cited:

Immunohistochemistry

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1.0 mg/ml

View all Integrin alpha 4/CD49d Antibodies »

Product Specifications

Immunogen

Synthetic 18 amino acid peptide from C-terminus of human Integrin alpha 4/CD49d.

Epitope

C-terminal domain of human

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Gorilla (100%), Gibbon (100%).

Specificity

Human Integrin alpha 4/CD49d. BLAST analysis of the peptide immunogen showed no homology with other human proteins.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Description

Product can be stored undiluted at 4C for up to 1 month.

Scientific Data Images for Integrin alpha 4/CD49d Antibody - BSA Free

Immunohistochemistry-Paraffin: Integrin alpha 4/CD49d Antibody - BSA Free [NB110-55525]

Immunohistochemistry-Paraffin: Integrin alpha 4/CD49d Antibody - BSA Free [NB110-55525]

Immunohistochemistry-Paraffin: Integrin alpha 4/CD49d Antibody - BSA Free [NB110-55525] - Human colon
Immunohistochemistry-Paraffin: Integrin alpha 4/CD49d Antibody - BSA Free [NB110-55525]

Immunohistochemistry-Paraffin: Integrin alpha 4/CD49d Antibody - BSA Free [NB110-55525]

Immunohistochemistry-Paraffin: Integrin alpha 4/CD49d Antibody - BSA Free [NB110-55525] - Human tonsil

Applications for Integrin alpha 4/CD49d Antibody - BSA Free

Application
Recommended Usage

Immunohistochemistry-Paraffin

2.5 - 5 ug/ml
Application Notes
.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.1% Sodium Azide

Concentration

1.0 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.

Background: Integrin alpha 4/CD49d

Integrin alpha 4 (also called CD49d) is a 150 kDa protein that possesses a large extracellular domain involved in ligand binding, a single transmembrane domain, and an intracellular regulatory domain possessing multiple sites for phosphorylation. Integrin alpha 4 forms heterodimers with integrins beta 1 and beta 7. Integrin alpha 4 is expressed on leukocytes and leukocyte precursors, neural crest cells, and developing skeletal muscles and is essential for embryogenesis, hematopoiesis, and immune responses. The presence of integrin alpha 4 promotes cell migration and inhibits cell spreading and contractility. Integrin alpha 4 function has been implicated in the pathogenesis of multiple diseases including asthma, rheumatoid arthritis, Crohn's disease, ulcerative colitis, hepatitis C, and multiple sclerosis, and therefore, modulation of integrin alpha 4 function has become an important target for drug discovery.

Alternate Names

CD49d, ITGA4, VLA-4

Entrez Gene IDs

3676 (Human)

Gene Symbol

ITGA4

Additional Integrin alpha 4/CD49d Products

Product Documents for Integrin alpha 4/CD49d Antibody - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for Integrin alpha 4/CD49d Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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