Integrin alpha 5 beta 1 Antibody (SG/19) [PE] - Chimeric

PE (Excitation = 488 nm, Emission = 575 nm)

Recombinant Monoclonal Rabbit IgG Clone # SG/19

Please see the vial label for concentration. If unlisted please contact technical services.

The original antibody was generated by immunizing BALB/c mice with Nalm-6 cells. (Uniprot# P05556)

This antibody binds human integrin alpha 5 beta 1 near the N-terminus. Epitope mapping of SG/19 revealed that Thr82 in the 1 subunit, located at the outer face of the boundary between the I-like and hybrid domains, was the key binding determinant for this antibody. Integrin alpha5 beta 1 is also known as fibronectin receptor and binds matrix macromolecules and proteinases and thereby stimulates angiogenesis. Integrin alpha5beta1, is a member of the integrin family, is a heterodimer composed by two subunits, alpha5 (ITGA5/CD49e) and beta1 (ITGB1/CD29), and both are necessary for complete biological functions. The interaction of VLA-5 with fibronectin plays an important role in regulating inflammatory cytokine production by human articular chondrocytes (From the Cell Migration Gateway ITGA5 ITGB1

Monoclonal

Rabbit

IgG

Protein A purified

PBS

0.05% Sodium Azide

Please see the vial label for concentration. If unlisted please contact technical services.

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Store at 4C in the dark.