Jak1 [p Tyr1034] Antibody (SR1138)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-21610

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-21610-100ul
NBP3-21610-50ul
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Key Product Details

Validated by

Biological Validation

Species Reactivity

Human

Applications

Immunohistochemistry, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # SR1138

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all Jak1 Antibodies »

Product Specifications

Immunogen

A synthesized peptide derived from human phospho-Jak1 [Tyr1034, Tyr1035] (Uniprot #: P23458)

Modification

p Tyr 1034

Specificity

Detects endogenous levels of total phospho-Jak1 [Tyr1034, Tyr1035]

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

133 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for Jak1 [p Tyr1034] Antibody (SR1138)

Western Blot: Jak1 [p Tyr 1034] Antibody (SR1138) [NBP3-21610] -

Western Blot: Jak1 [p Tyr 1034] Antibody (SR1138) [NBP3-21610] - Western blot analysis using NBP3-21610 in Ramos treated with pervanadate cell lysate.

Applications for Jak1 [p Tyr1034] Antibody (SR1138)

Application
Recommended Usage

Immunohistochemistry

1:50-1:100

Western Blot

1:500-1:2000

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, pH 7.4, 150mM NaCl, 50% glycerol.

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Jak1

Janus kinase 1 (JAK1), is a member of a new class of protein-tyrosine kinases (PTK) characterised by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all the hallmarks of a protein kinase, although its structure differs significantly from that of the PTK and threonine/serine kinase family members. JAK1 is a large, widely expressed membrane-associated phosphoprotein. It is involved in the interferon-alpha/beta and -gamma signal transduction pathways. The reciprocal interdependence between JAK1 and TYK2 activities in the interferon-alpha pathway, and between JAK1 and JAK2 in the interferon-gamma pathway, may reflect a requirement for these kinases in the correct assembly of interferon recpeptor complexes. These kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signalling proteins and a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs.

Long Name

Janus Kinase 1

Alternate Names

EC 2.7.10, JAK-1, JAK1Atyrosine-protein kinase JAK1, JAK1B, Janus kinase 1EC 2.7.10.2, JTK3

Gene Symbol

JAK1

Additional Jak1 Products

Product Documents for Jak1 [p Tyr1034] Antibody (SR1138)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Jak1 [p Tyr1034] Antibody (SR1138)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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