Jak2 [p Tyr1007] Antibody (SR1129)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-21579

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
Catalog #
Availability
Size / Price
Qty
NBP3-21579-100ul
NBP3-21579-50ul
Print Quote
Bulk Order
100% Guarantee

Key Product Details

Validated by

Biological Validation

Species Reactivity

Human, Mouse, Rat

Applications

Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # SR1129

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all Jak2 Antibodies »

Product Specifications

Immunogen

A synthesized peptide derived from human phospho-Jak2 [Tyr1007, Tyr1008] (Uniprot #: O60674)

Modification

p Tyr1007

Specificity

Detects endogenous levels of total phospho-Jak2 [Tyr1007, Tyr1008]

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

130 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for Jak2 [p Tyr1007] Antibody (SR1129)

Immunocytochemistry/Immunofluorescence: Jak2 [p Tyr 1007] Antibody (SR1129) [NBP3-21579] -

Immunocytochemistry/Immunofluorescence: Jak2 [p Tyr 1007] Antibody (SR1129) [NBP3-21579] - Immunofluorescent analysis of Jurkat cells treated with Pervanadate, using NBP3-21579.

Immunohistochemistry: Jak2 [p Tyr 1007] Antibody (SR1129) [NBP3-21579] -

Immunohistochemistry: Jak2 [p Tyr 1007] Antibody (SR1129) [NBP3-21579] - Immunohistochemical analysis of paraffin-embedded human cervix cancer, using NBP3-21579.

Western Blot: Jak2 [p Tyr 1007] Antibody (SR1129) [NBP3-21579] -

Western Blot: Jak2 [p Tyr 1007] Antibody (SR1129) [NBP3-21579] - Western blot analysis using NBP3-21579 in Jurkat cell lysates treated with Pervanadate.

Applications for Jak2 [p Tyr1007] Antibody (SR1129)

Application
Recommended Usage

Flow Cytometry

1:30

Immunocytochemistry/ Immunofluorescence

1:50-1:200

Immunohistochemistry

1:50-1:200

Immunoprecipitation

1:50

Western Blot

1:500-1:2000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, pH 7.4, 150mM NaCl, 50% glycerol.

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Jak2

Jak2 is a member of the Janus family tyrosine kinases (Jaks), whose function is to transduce extracellular signals from cytokines and interferons. Jaks associate with cytokine receptors; upon ligand binding, Jaks phosphorylate the receptor. The phosphorylated receptors are bound by SH2-containing proteins, one class of which is the signal transducers and activators of transcription (STATs). Activated STATs, then, translocate to the nucleus to mediate gene transcription (1,2). Tyr1007/1008 of Jak2 are the homologous Tyr1054/1055 in Tyk2, and phosphorylation at these residues is needed for Tyk2 activation (3). A chromosomal aberration involving Jak2 is found in a form of pre-B acute myeloid leukemia (4).

Long Name

Janus Kinase 2

Alternate Names

EC 2.7.10, EC 2.7.10.2, JAK-2, Janus kinase 2Janus kinase 2 (a protein tyrosine kinase), JTK10, tyrosine-protein kinase JAK2

Gene Symbol

JAK2

Additional Jak2 Products

Product Documents for Jak2 [p Tyr1007] Antibody (SR1129)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for Jak2 [p Tyr1007] Antibody (SR1129)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Privacy and Cookie Policy
Site Map
© Copyright 2024 Bio-Techne. All Rights Reserved.