KA2/GRIK5/Glutamate Receptor KA2 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-36959

Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Bovine (100%), Rat (100%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Peptide ELISA, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG

Concentration

0.5 mg/ml

View all KA2/GRIK5 Antibodies »

Product Specifications

Immunogen

Peptide with sequence C-GPAGPRELAEHE corresponding to C-Terminus according to NP_002079.3.

Epitope

C-Terminus

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for KA2/GRIK5/Glutamate Receptor KA2 Antibody

Immunohistochemistry-Paraffin: KA2/GRIK5/Glutamate Receptor KA2 Antibody [NBP1-36959]

Immunohistochemistry-Paraffin: KA2/GRIK5/Glutamate Receptor KA2 Antibody [NBP1-36959]

Immunohistochemistry-Paraffin: KA2/GRIK5/Glutamate Receptor KA2 Antibody [NBP1-36959] - (3.75ug/ml) staining of paraffin embedded Human Cortex. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

Applications for KA2/GRIK5/Glutamate Receptor KA2 Antibody

Application
Recommended Usage

Immunohistochemistry

3.75 ug/ml

Immunohistochemistry-Paraffin

3.75 ug/ml

Peptide ELISA

Detection limit 1:32000

Western Blot

1 ug/ml
Application Notes
Western blot: Preliminary experiments gave an approx. 26kDa band in Human Brain (Frontal Cortex and Hippocampus) lysates after 1ug/ml antibody staining. Please note that currently we can not find an explanation in the literature for the band we observe given the calculated size of 109kDa according to NP_002079.3. The 26kDa band was successfully blocked by incubation with the immunizing peptide.
IHC: Paraffin embedded Human Brain (Cortex).

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: KA2/GRIK5

Glutamate receptor KA2 is a protein that interacts with glutamate, an excitatory neurotransmitter, in the central nervous system and that has two isoforms, measuring 980 and 981 amino acids in length, with weights of approximately 109 and 110 kDa respectively. Current studies are being done on diseases and disorders related to this protein including temporal lobe epilepsy, embryonal carcinoma, Parkinson's disease, schizophrenia, retinoblastoma, neruoblastoma, thyroiditis, and neuronitis. Glutamate receptor KA2 has also been shown to have interactions with GOLM1, GPAA1, LRSAM1, DLG4, and GRID2 in pathways such as the glutamic acid signaling, transmission across chemical synapses, and activation of kainite receptor pathways.

Long Name

Glutamate Receptor KA2

Alternate Names

EAA2, GluK5, GRIK2, GRIK5

Entrez Gene IDs

2901 (Human); 24407 (Rat)

Gene Symbol

GRIK5

UniProt

NP_002079.3 (Human)

Additional KA2/GRIK5 Products

Product Documents for KA2/GRIK5/Glutamate Receptor KA2 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for KA2/GRIK5/Glutamate Receptor KA2 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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