KCNK1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-84987

Novus Biologicals, part of Bio-Techne
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NBP1-84987
NBP1-84987-25ul
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Key Product Details

Species Reactivity

Human

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all KCNK1 Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: YVKKDKDEDQVHIIEHDQLSFSSITDQAAGMKEDQKQNEPFVATQSSACVDGPAN

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: Rat (82%). Reactivity reported in scientific literature (PMID: 21964404)

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for KCNK1 Antibody

Immunocytochemistry/ Immunofluorescence: KCNK1 Antibody [NBP1-84987]

Immunocytochemistry/ Immunofluorescence: KCNK1 Antibody [NBP1-84987]

Immunocytochemistry/Immunofluorescence: KCNK1 Antibody [NBP1-84987] - Immunofluorescent staining of human cell line HeLa shows localization to vesicles.
Immunohistochemistry-Paraffin: KCNK1 Antibody [NBP1-84987]

Immunohistochemistry-Paraffin: KCNK1 Antibody [NBP1-84987]

Immunohistochemistry-Paraffin: KCNK1 Antibody [NBP1-84987] - Staining of human cerebellum shows strong cytoplasmic positivity in Purkinje cells.

Applications for KCNK1 Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

0.25-2 ug/ml

Immunohistochemistry

1:200 - 1:500

Immunohistochemistry-Paraffin

1:200 - 1:500
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended. Immunocytochemistry/Immunofluorescence Fixation Permeabilization: Use PFA/Triton X-100.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: KCNK1

K+ channels are divided into three subclasses, reflecting the number of transmembrane segments (TMS), which are designated 6TMS, 4TMS and 2TMS. Members of the 4TMS class contain two distinct pore regions, and include TASK, TREK, TRAAK and TWIK. TWIK-1 mRNA is expressed abundantly in brain and at lower levels in lung, kidney and skeletal muscle. The molecular weight of TWIK-1 in mouse brain is 40 kDa under reducing conditions. TWIK-2 shares low sequence homology with other mammalian family group members, and only 34% homology with TWIK-1. Human TWIK-2 is expressed in pancreas, placenta and heart, while mouse TWIK-2 is expressed in liver. TWIK-2 is inhibited by intracellular, but not extracellular, acidification.

Long Name

Potassium channel subfamily K member 1

Alternate Names

HOHO1, KCNO1, TWIK1

Gene Symbol

KCNK1

Additional KCNK1 Products

Product Documents for KCNK1 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for KCNK1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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