KCNN3 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-55459

Novus Biologicals, part of Bio-Techne
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NBP2-55459
NBP2-55459-25ul
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Mouse (95%), Rat (95%). Backed by our 100% Guarantee.

Applications

Immunocytochemistry/ Immunofluorescence

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all KCNN3 Antibodies »

Product Summary for KCNN3 Antibody

Immunogen

This antibody was developed against a recombinant protein corresponding to the following amino acid sequence: NLIEAETEGQPLQLFSPSNPPEIVISSREDNHAHQTLLHHPNATHNHQHAGTTASSTTFPKANKRK

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for KCNN3 Antibody

Immunocytochemistry/ Immunofluorescence: KCNN3 Antibody [NBP2-55459]

Immunocytochemistry/ Immunofluorescence: KCNN3 Antibody [NBP2-55459]

Immunocytochemistry/Immunofluorescence: KCNN3 Antibody [NBP2-55459] - Staining of human cell line PC-3 shows localization to nucleoplasm.

Applications for KCNN3 Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

0.25-2 ug/ml
Application Notes
Immunocytochemistry/Immunofluorescence Fixation Permeabilization: Use PFA/Triton X-100.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: KCNN3

Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. This gene contains two CAG repeat regions in the coding sequence. It was thought that expansion of one or both of these repeats could lead to an increased susceptibility to schizophrenia or bipolar disorder, but studies indicate that this is probably not the case. This gene is a member of the KCNN family of potassium channel genes. Two transcript variants encoding two different isoforms have been found for this gene. One of the variants lacks the CAG repeat regions.

Long Name

Small conductance calcium-activated potassium channel protein 3

Alternate Names

K3, KCa2.3, SK3, SKCa 3, SKCa3

Gene Symbol

KCNN3

Additional KCNN3 Products

Product Documents for KCNN3 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for KCNN3 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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