Kir2.1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-87709

Novus Biologicals, part of Bio-Techne
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NBP1-87709
NBP1-87709-25ul
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Mouse (96%), Rat (98%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Kir2.1 Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: YEVPNTPLCSARDLAEKKYILSNANSFCYENEVALTSKEEDDSENGVPES

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Kir2.1 Antibody

Immunohistochemistry-Paraffin: Kir2.1 Antibody [NBP1-87709]

Immunohistochemistry-Paraffin: Kir2.1 Antibody [NBP1-87709]

Immunohistochemistry-Paraffin: Kir2.1 Antibody [NBP1-87709] - Staining of human heart muscle shows strong cytoplasmic positivity in cardiomyocytes.
Immunohistochemistry: Kir2.1 Antibody [NBP1-87709]

Immunohistochemistry: Kir2.1 Antibody [NBP1-87709]

Immunohistochemistry: Kir2.1 Antibody [NBP1-87709] - Staining of human colon shows strong cytoplasmic and membrane positivity in glandular cells.
Immunohistochemistry-Paraffin: Kir2.1 Antibody [NBP1-87709]

Immunohistochemistry-Paraffin: Kir2.1 Antibody [NBP1-87709]

Immunohistochemistry-Paraffin: Kir2.1 Antibody [NBP1-87709] - Staining of human fallopian tube shows moderate cytoplasmic positivity in glandular cells.
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Applications for Kir2.1 Antibody

Application
Recommended Usage

Immunohistochemistry

1:500 - 1:1000

Immunohistochemistry-Paraffin

1:500 - 1:1000
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Kir2.1

FUNCTION: Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium or cesium.; Tissue specificity: Heart, brain, placenta, lung, skeletal muscle, and kidney. Diffusely distributed throughout the brain.; Subcellular location: Membrane, Multi-pass membrane protein.; Involvement in disease: Defects in KCNJ2 are the cause of long QT syndrome type 7 (LQT7); also called Andersen syndrome or Andersen cardiodysrhythmic periodic paralysis. Long QT syndromes are heart disorders characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to excercise or emotional stress. LQT7 manifests itself as a clinical triad consisting of potassium-sensitive periodic paralysis, ventricular ectopy and dysmorphic features.; Defects in KCNJ2 are the cause of short QT syndrome type 3 (SQT3). Short QT syndromes are heart disorders characterized by idiopathic persistently and uniformly short QT interval on ECG in the absence of structural heart disease in affected individuals. They cause syncope and sudden death. SQT3 has a unique ECG phenotype characterized by asymmetrical T waves.

Long Name

Inward Rectifier K(+) Channel Kir2.1

Alternate Names

ATFB9, HIRK1, IRK1, KCNJ2, LQT7, SQT3

Gene Symbol

KCNJ2

Additional Kir2.1 Products

Product Documents for Kir2.1 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Kir2.1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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