Kir6.2 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB100-93410

Novus Biologicals, part of Bio-Techne
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NB100-93410
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Canine (100%), Mouse (100%), Rat (100%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Peptide ELISA, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG

Concentration

0.5 mg/ml

View all Kir6.2 Antibodies »

Product Specifications

Immunogen

Peptide with sequence ERRARFVSKKGNC corresponding to internal region (near N-Terminus) according to Uniprot Mouse NP_034732.1.

Epitope

ERRARFVSKKGNC

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for Kir6.2 Antibody

Western Blot: Kir6.2 Antibody [NB100-93410]

Western Blot: Kir6.2 Antibody [NB100-93410]

Western Blot: Kir6.2 Antibody [NB100-93410] - Analysis of Kir6.2 in Human Muscle lysate (35ug protein in RIPA buffer) using NB100-93410 at 0.1ug/ml. Primary incubation was 1 hour. Detected by chemiluminescence.
Immunohistochemistry-Paraffin: Kir6.2 Antibody [NB100-93410]

Immunohistochemistry-Paraffin: Kir6.2 Antibody [NB100-93410]

Immunohistochemistry-Paraffin: Kir6.2 Antibody [NB100-93410] - (3.8ug/ml) staining of paraffin embedded Human Pancreas. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

Applications for Kir6.2 Antibody

Application
Recommended Usage

Immunohistochemistry

3 - 5 ug/ml

Immunohistochemistry-Paraffin

3 - 5 ug/ml

Peptide ELISA

Detection limit 1:64000

Western Blot

0.01 - 0.03 ug/ml
Application Notes
WB: Approx. 45 kDa band observed in human skeletal muscle lysates (calculated MW of 43.6 kDa band according to NP_034732.1). IHC-P: Human pancreas shows variable staining across the islet of langerhans.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: Kir6.2

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and is found associated with the sulfonylurea receptor SUR. Mutations in this gene are a cause of familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI), an autosomal recessive disorder characterized by unregulated insulin secretion. Defects in this gene may also contribute to autosomal dominant non-insulin-dependent diabetes mellitus type II (NIDDM), transient neonatal diabetes mellitus type 3 (TNDM3), and permanent neonatal diabetes mellitus (PNDM). [provided by RefSeq]

Long Name

ATP-sensitive inward rectifier potassium channel 11

Alternate Names

IKATP, KCNJ11

Entrez Gene IDs

3767 (Human); 16514 (Mouse); 83535 (Rat)

Gene Symbol

KCNJ11

UniProt

NP_034732.1 (Mouse)

Additional Kir6.2 Products

Product Documents for Kir6.2 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Kir6.2 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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