L1CAM Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-86544

Novus Biologicals, part of Bio-Techne
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NBP1-86544
NBP1-86544-25ul
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Key Product Details

Validated by

Orthogonal Validation

Species Reactivity

Validated:

Human

Cited:

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all L1CAM Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: ELRTHNLTDLSPHLRYRFQLQATTKEGPGEAIVREGGTMALSGISDFGNISATAGENYSVVSWVPKEGQCNFRFHILFKALGEEKGGASLSPQYVSYNQSSYTQWDLQPDTDYEIHLFKERMFRHQMAVKTNGTGRVRLPPAGFATE

Reactivity Notes

Human reactivity reported in scientific literature (PMID: 25862471).

Marker

Axon Marker

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for L1CAM Antibody

Immunohistochemistry-Paraffin: L1CAM Antibody [NBP1-86544]

Immunohistochemistry-Paraffin: L1CAM Antibody [NBP1-86544]

Immunohistochemistry-Paraffin: L1CAM Antibody [NBP1-86544] - Staining in human cerebral cortex and skeletal muscle tissues.. Corresponding L1CAM RNA-seq data are presented for the same tissues.
Immunohistochemistry-Paraffin: L1CAM Antibody [NBP1-86544]

Immunohistochemistry-Paraffin: L1CAM Antibody [NBP1-86544]

Immunohistochemistry-Paraffin: L1CAM Antibody [NBP1-86544] - Staining of human cerebral cortex shows moderate cytoplasmic positivity in neuropil.
Immunohistochemistry-Paraffin: L1CAM Antibody [NBP1-86544]

Immunohistochemistry-Paraffin: L1CAM Antibody [NBP1-86544]

Immunohistochemistry-Paraffin: L1CAM Antibody [NBP1-86544] - Staining of human skeletal muscle shows no positivity in myocytes as expected.
View 2 more images

Applications for L1CAM Antibody

Application
Recommended Usage

Immunohistochemistry

1:200 - 1:500

Immunohistochemistry-Paraffin

1:200 - 1:500
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: L1CAM

The L1CAM gene, which is located in Xq28, is involved in three distinct conditions: 1) HSAS (hydrocephalus-stenosis of the aqueduct of Sylvius); 2) MASA (mental retardation, aphasia, shuffling gait, adductus thumbs); and 3) SPG1 (spastic paraplegia). The L1, neural cell adhesion molecule (L1CAM) also plays an important role in axon growth, fasciculation, neural migration and in mediating neuronal differentiation. Expression of L1 protein is restricted to tissues arising from neuroectoderm.

Long Name

Cell Adhesion Molecule L1

Alternate Names

CAML1, CD171, HSAS, HSAS1, MASA, MIC5, NCAM-L1, S10, SPG1

Gene Symbol

L1CAM

Additional L1CAM Products

Product Documents for L1CAM Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for L1CAM Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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