Lactoperoxidase Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-87010

Novus Biologicals, part of Bio-Techne
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NBP1-87010
NBP1-87010-25ul
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Key Product Details

Validated by

Orthogonal Validation

Species Reactivity

Validated:

Human, Mouse

Cited:

Mouse

Applications

Validated:

Immunohistochemistry, Immunohistochemistry-Paraffin

Cited:

IF/IHC

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Lactoperoxidase Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: IVGYLNEEGVLDQNRSLLFMQWGQIVDHDLDFAPDTELGSSEYSKAQCDEYCIQGDNCFPIMFPPNDPKAGTQGKCMPFFRAGFVCPTPPYKSLAR

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: Rat (82%) Use in Mouse reported in scientific literature (PMID:29858825).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Lactoperoxidase Antibody

Immunohistochemistry-Paraffin: Lactoperoxidase Antibody [NBP1-87010]

Immunohistochemistry-Paraffin: Lactoperoxidase Antibody [NBP1-87010]

Immunohistochemistry-Paraffin: Lactoperoxidase Antibody [NBP1-87010] - Staining of human colon shows low expression as expected.
Immunohistochemistry-Paraffin: Lactoperoxidase Antibody [NBP1-87010]

Immunohistochemistry-Paraffin: Lactoperoxidase Antibody [NBP1-87010]

Immunohistochemistry-Paraffin: Lactoperoxidase Antibody [NBP1-87010] - Staining of human salivary gland shows strong cytoplasmic positivity in glandular cells.
Immunohistochemistry-Paraffin: Lactoperoxidase Antibody [NBP1-87010]

Immunohistochemistry-Paraffin: Lactoperoxidase Antibody [NBP1-87010]

Immunohistochemistry-Paraffin: Lactoperoxidase Antibody [NBP1-87010] - Staining in human salivary gland and colon tissues using anti-LPO antibody. Corresponding LPO RNA-seq data are presented for the same tissues.

Applications for Lactoperoxidase Antibody

Application
Recommended Usage

Immunohistochemistry

1:1000 - 1:2500

Immunohistochemistry-Paraffin

1:1000 - 1:2500
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Lactoperoxidase

Lactoperoxidase is an antibacterial agent in cow milk. The heme protein lactoperoxidase (LPO), also referred to as salivary peroxidase (SPO), is an oxidoreductase secreted into milk. LPO belongs to the XPO subfamily of the peroxidase family. It is expressed in mammary and salivary glands, and in the presence of H2O2, LPO acts as a catalyst for the oxidation of many phenols and aromatic amines. It is crucial for protecting the lactating mammary gland and intestinal tract of newborn infants against microorganisms. LPO binds one calcium ion per heterodimer and one heme B (iron-protoporphyrin IX) group covalently per heterodimer. The LPO gene, which spans 28 kb, is similar in gene organization and sequence to the peroxidase genes MPO and EPX, suggesting the possibility that these genes evolved from a common ancestral gene. The LPO and MPO genes are arranged in a tail-to-tail manner on chromosome 17q23.1.

Alternate Names

EC 1.11.1, lactoperoxidase, MGC129990, MGC129991, Salivary peroxidase, SAPX, SPOEC 1.11.1.7

Gene Symbol

LPO

Additional Lactoperoxidase Products

Product Documents for Lactoperoxidase Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Lactoperoxidase Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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