Lamin B1 Antibody (ZL-5)

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-45674

Recombinant Monoclonal Antibody.
Novus Biologicals, part of Bio-Techne
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NBP1-45674
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat, Chicken

Cited:

Mouse

Applications

Validated:

ELISA, Immunocytochemistry/ Immunofluorescence, Immunoprecipitation, Western Blot

Cited:

Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG1 kappa Clone # ZL-5

Concentration

0.2 mg/ml

View all Lamin B1 Antibodies »

Product Specifications

Immunogen

Recombinant human Lamin B.

Specificity

The antibody recognizes the 68 kDa lamin B1 isoform. Reactivity with other lamin isoforms has not been detected.

Marker

Nuclear Envelope Marker

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG1 kappa

Applications for Lamin B1 Antibody (ZL-5)

Application
Recommended Usage

ELISA

0.2 - 1 ug/mL

Immunocytochemistry/ Immunofluorescence

10 - 15 ug/mL

Immunoprecipitation

5 ug/mL

Western Blot

0.5 - 2 ug/mL

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

PBS, 1.0% BSA, 50% Glycerol

Preservative

0.9% Sodium Azide

Concentration

0.2 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: Lamin B1

The lamins form a meshwork of filaments on the inner, or nucleoplasmic, surface of the nuclear envelope. Currently, mammalian species appear to contain at least four major lamins, called A, B1, B2, and C, of which two (A and C) arise by alternative splicing of the same gene and two minor lamins, D and E, whose molecular weight varies from species to species. Nuclei of embryonic and lymphiod cells contain only lamin B1. Mutations affecting A-type lamins have been associated with a variety of human diseases, including muscular dystrophy, cardiomyopathy, lipodystrophy, and progeria, but mutations in B-type lamins have never been identified in humans. Homozygous lamin B1 mutant mice survive embryonic development but died at birth with defects in lung and bone. Cells obtained from mutant lamin B1 mice are defective in differentiation, polyploidy and senesce prematurely.

Alternate Names

ADLD, LMN2, LMNB1

Entrez Gene IDs

4001 (Human)

Gene Symbol

LMNB1

Additional Lamin B1 Products

Product Documents for Lamin B1 Antibody (ZL-5)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for Lamin B1 Antibody (ZL-5)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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