LANA2 Antibody (CM-A807) [DyLight 405]

Novus Biologicals, part of Bio-Techne | Catalog # NB200-167V

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Product Datasheet / COA / SDS

View Available Conjugates View Available Formulations

Conjugate

Catalog #

Alexa Fluor 350

NB200-167AF350

Alexa Fluor 405

NB200-167AF405

Alexa Fluor 488

NB200-167AF488

Alexa Fluor 532

NB200-167AF532

Alexa Fluor 594

NB200-167AF594

Alexa Fluor 647

NB200-167AF647

Alexa Fluor 700

NB200-167AF700

Alexa Fluor 750

NB200-167AF750

Biotin

NB200-167B

CoraFluor 1

NB200-167CL1

DyLight 350

NB200-167UV

DyLight 488

NB200-167G

DyLight 550

NB200-167R

DyLight 594

NB200-167DL594

DyLight 650

NB200-167C

DyLight 680

NB200-167FR

DyLight 755

NB200-167IR

FITC

NB200-167F

HRP

NB200-167H

Janelia Fluor 525

NB200-167JF525

Janelia Fluor 549

NB200-167JF549

Janelia Fluor 646

NB200-167JF646

Janelia Fluor 669

NB200-167JF669

mFluor Violet 450 SE

NB200-167MFV450

mFluor Violet 500 SE

NB200-167MFV500

mFluor Violet 610 SE

NB200-167MFV610

Forumulation

Catalog #

BSA Free

NB200-167

Azide and BSA Free

NBP2-80826

Product Specifications
Applications
Preparation & Storage
Background
Product Documents
Specific Notices

Key Product Details

Species Reactivity

Human, Mouse, Virus

Applications

ELISA, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Frozen, Immunohistochemistry-Paraffin, Immunoprecipitation, Knockout Validated, Western Blot

Label

DyLight 405 (Excitation = 400 nm, Emission = 420 nm)

Antibody Source

Monoclonal Mouse IgG₁ kappa Clone # CM-A807

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all LANA2 Antibodies »

Product Specifications

Immunogen

Recombinant LANA2 fusion protein.

Reactivity Notes

Reacts with viral LANA2 protein and shows no cross-reactivity to cellular proteins. Also reacts with human and mouse viral KSHV proteins.

Localization

Nuclear

Specificity

This is specific for KSHV LANA2 (residues 143-310 epitope recognition).

Clonality

Monoclonal

Host

Mouse

Isotype

IgG₁ kappa

Applications for LANA2 Antibody (CM-A807) [DyLight 405]

Application

Recommended Usage

ELISA

Optimal dilutions of this antibody should be experimentally determined.

Immunocytochemistry/ Immunofluorescence

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry-Frozen

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry-Paraffin

Optimal dilutions of this antibody should be experimentally determined.

Immunoprecipitation

Optimal dilutions of this antibody should be experimentally determined.

Knockout Validated

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.

Application Notes

Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

50mM Sodium Borate

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: LANA2

LANA2 (latency-associated nuclear antigen 2; also known as viral interferon regulatory factor 3) is a Kaposi's sarcoma-associated herpesvirus (KSHV) latent protein which is encoded by ORFK10.5 and is exclusively expressed by virus infected B- cells. LANA2 has been shown to be critical in KSHV-mediated tumorigenesis as it inhibits p53 function, dsRNA-activated protein kinase R (PKR)-dependent apoptosis, nuclear factor kB activity, interferon regulatory factor 7-mediated interferon signal transduction and virus-mediated transcriptional activation of the alpha-interferon promoter. LANA2 stabilizes and triggers the induction of HIF-1alpha's transcriptional activity and disrupts PODs (PML oncogenic domains). Moreover, LANA2 has been shown to be required for the survival of primary effusion lymphoma (PEL) cells infected with KSHV alone or dually infected by Epstein-Barr virus (EBV) and KSHV, wherein it shows nuclear and cytoplasmic expression.

Alternate Names

LANA 2, LANA-2, Latency-associated nuclear antigen 2, vIRF 3, vIRF3, vIRF-3

Additional LANA2 Products

Product Documents for LANA2 Antibody (CM-A807) [DyLight 405]

Product Datasheets

Download Product Datasheets

COA

SDS

Product Specific Notices for LANA2 Antibody (CM-A807) [DyLight 405]

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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