LIM kinase 2 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # H00003985-D01P

Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Human, Mouse

Applications

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all LIM kinase 2 Antibodies »

Product Specifications

Immunogen

LIMK2 (NP_001026971.1, 1 a.a. - 686 a.a.) full-length human protein. MGSYLSVPAYFTSRDLFRCSECQDSLTNWYYEKDGKLYCPKDYWGKFGEFCHGCSLLMTGPFMVAGEFKYHPECFACMSCKVIIEDGDAYALVQHATLYCGKCHNEVVLAPMFERLSTESVQEQLPYSVTLISMPATTEGRRGFSVSVESACSNYATTVQVKEVNRMHISPNNRNAIHPGDRILEINGTPVRTLRVEEVEDAISQTSQTLQLLIEHDPVSQRLDQLRLEARLAPHMQNAGHPHALSTLDTKENLEGTLRRRSLRRSNSISKSPGPSSPKEPLLFSRDISRSESLRCSSSYSQQIFRPCDLIHGEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRSMDPFPWQQKVRFAKGIASGMAYLHSMCIIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVVGNPYWMAPEMLNGKSYDETVDIFSFGIVLCEIIGQVYADPDCLPRTLDFGLNVKLFWEKFVPTDCPPAFFPLAAICCRLEPESRAPPGAAGEGPGCADDEGPVRRQGKVTIKYDPKELRKHLNLEEWILEQLTRLYDCQEEEISELEIDVDELLDMESDDAWASRVKELLVDCYKPTEAFISGLLDKIRAMQKLSTPQKK

Specificity

LIMK2 - LIM domain kinase 2,

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Description

Quality control test: Antibody reactive against mammalian transfected lysate.

Scientific Data Images for LIM kinase 2 Antibody

Western Blot: LIM kinase 2 Antibody [H00003985-D01P]

Western Blot: LIM kinase 2 Antibody [H00003985-D01P]

Western Blot: LIM kinase 2 Antibody [H00003985-D01P] - Analysis of LIMK2 expression in mouse kidney.
Western Blot: LIM kinase 2 Antibody [H00003985-D01P]

Western Blot: LIM kinase 2 Antibody [H00003985-D01P]

Western Blot: LIM kinase 2 Antibody [H00003985-D01P] - analysis of LIMK2 expression in transfected 293T cell line by LIMK2 MaxPab rabbit polyclonal antibody. Lane 1: LIMK2 transfected lysate (77.90 KDa). Lane 2: Non-transfected lysate.
Western Blot: LIM kinase 2 Antibody [H00003985-D01P]

Western Blot: LIM kinase 2 Antibody [H00003985-D01P]

Western Blot: LIM kinase 2 Antibody [H00003985-D01P] - Analysis of LIMK2 expression in human liver.
View 1 more images

Applications for LIM kinase 2 Antibody

Application
Recommended Usage

Western Blot

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Antibody reactivity against tissue lysate and transfected lysate for WB. It has been used for ELISA.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS (pH 7.4)

Preservative

No Preservative

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: LIM kinase 2

There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Long Name

LIM domain kinase 2

Alternate Names

LIMK-2, LIMK2

Entrez Gene IDs

3985 (Human)

Gene Symbol

LIMK2

UniProt

NP_001026971.1 (Human)

Additional LIM kinase 2 Products

Product Documents for LIM kinase 2 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for LIM kinase 2 Antibody

This product is produced by and distributed for Abnova, a company based in Taiwan.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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