LIMPII/SR-B2 Antibody [Janelia Fluor® 646]

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-77326JF646

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Product Datasheet / COA / SDS

View Available Conjugates View Available Formulations

Conjugate

Catalog #

Alexa Fluor 350

NBP1-77326AF350

Alexa Fluor 405

NBP1-77326AF405

Alexa Fluor 488

NBP1-77326AF488

Alexa Fluor 532

NBP1-77326AF532

Alexa Fluor 594

NBP1-77326AF594

Alexa Fluor 647

NBP1-77326AF647

Alexa Fluor 700

NBP1-77326AF700

Alexa Fluor 750

NBP1-77326AF750

Biotin

NBP1-77326B

CoraFluor 1

NBP1-77326CL1

DyLight 350

NBP1-77326UV

DyLight 405

NBP1-77326V

DyLight 488

NBP1-77326G

DyLight 550

NBP1-77326R

DyLight 594

NBP1-77326DL594

DyLight 650

NBP1-77326C

DyLight 680

NBP1-77326FR

DyLight 755

NBP1-77326IR

FITC

NBP1-77326F

HRP

NBP1-77326H

Janelia Fluor 525

NBP1-77326JF525

Janelia Fluor 549

NBP1-77326JF549

Janelia Fluor 585

NBP1-77326JF585

Janelia Fluor 635

NBP1-77326JF635

Janelia Fluor 669

NBP1-77326JF669

mFluor Violet 450 SE

NBP1-77326MFV450

mFluor Violet 500 SE

NBP1-77326MFV500

mFluor Violet 610 SE

NBP1-77326MFV610

PerCP

NBP1-77326PCP

Forumulation

Catalog #

BSA Free

NBP1-77326

Product Summary
Applications
Preparation & Storage
Background
Product Documents
Specific Notices

Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat

Applications

ELISA, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Frozen, Immunohistochemistry-Paraffin, Simple Western, Western Blot

Label

Janelia Fluor 646

Antibody Source

Polyclonal Rabbit IgG

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all LIMPII/SR-B2 Antibodies »

Product Summary for LIMPII/SR-B2 Antibody [Janelia Fluor® 646]

Immunogen

Antibody was raised against a 16 amino acid synthetic peptide from near the center of human LIMP2. The immunogen is located within amino acids 70 - 120 of LIMP2. Amino Acid Squence: EEVGPYTYRELRNKAN

Reactivity Notes

Rat reactivity reported in the scientific literature (PMID: 23825416) and by customer review.

Marker

Lysosome Marker

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Applications for LIMPII/SR-B2 Antibody [Janelia Fluor® 646]

Application

Recommended Usage

ELISA

Optimal dilutions of this antibody should be experimentally determined.

Immunocytochemistry/ Immunofluorescence

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry-Frozen

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry-Paraffin

Optimal dilutions of this antibody should be experimentally determined.

Simple Western

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.

Application Notes

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Peptide affinity purified

Formulation

50mM Sodium Borate

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: LIMPII/SR-B2

High density lipoproteins (HDLs) play a critical role in cholesterol metabolism and their plasma concentrations are inversely correlated with risk for atherosclerosis. SR-BI and SR-BII (previously known as SR-BI.2) are the alternatively spliced products of a single gene. SR-BII differs from SR-BI in that the encoded c-terminal cytoplasmic domain is almost completely different. SR-BII binds HDLs and mediates selective uptake of HDL cholesteryl ester, but with an approximately 4-fold lower efficiency than SR-BI. Nuclease protection assays show SR-BII to be abundant in mouse tissues expressing SR-BI, with SR-BII expression found in liver, adrenal glands, and testes. Although the role of SR-BII is not completely clear, research suggests that it may be a functional HDL receptor. In addition, SR-BII mRNA results from the alternative splicing of SR-BI precursor transcripts with the SR-BII isoform mediating selective transfer of lipid between HDL and cells. The relative expression and functional activities of these two isoforms create a potential means of regulating selective lipid transfer between HDL and cells.

Long Name

Lysosomal Integral Membrane Protein II

Alternate Names

CD36L2, LPG85, SCARB2, SR-B2, SR-BII, SRB2

Gene Symbol

SCARB2

Additional LIMPII/SR-B2 Products

Product Documents for LIMPII/SR-B2 Antibody [Janelia Fluor® 646]

Product Datasheets

Download Product Datasheets

COA

SDS

Product Specific Notices for LIMPII/SR-B2 Antibody [Janelia Fluor® 646]

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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