Lipase A Antibody [Biotin]

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-54155B

Novus Biologicals, part of Bio-Techne
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NBP1-54155
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Key Product Details

Species Reactivity

Validated:

Human, Mouse

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Simple Western, Western Blot

Label

Biotin

Antibody Source

Polyclonal Rabbit IgG

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all LIPA Antibodies »

Product Summary for Lipase A Antibody [Biotin]

Immunogen

Partial recombinant protein made to an internal region of the human Lipase A protein (within residues 150-300). [Swiss-Prot P38571]

Reactivity Notes

Immunogen sequence has 82% identity to pig and 73% identity to rat and cow.

Localization

Lysosome.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Applications for Lipase A Antibody [Biotin]

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry-Paraffin

Optimal dilutions of this antibody should be experimentally determined.

Simple Western

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: LIPA

Lipase A is a critical enzyme for metabolism, sequestration and degradation of cholesterol. When LIPA is not effective in liver and kidney cells, lipoprotein cholesterol accumulates and leads to atherosclerosis, inflammation, Type 2 diabetes, and chronic kidney disease. In Wolman disease, deficiency of LIPA causes buildup of cholesterol in spleen, liver, bone marrow, intestine, adrenal glands and lymph nodes, which eventually causes such toxicity in children affected that they rarely live past 1 year of age. Intracellularly, LIPA mediates the uptake of cholesterol by the endosomal/lysosomal compartment, and hydrolyzes cholesterol esterases.

Long Name

Lipase A

Alternate Names

CESD, Lipase A

Gene Symbol

LIPA

Additional LIPA Products

Product Documents for Lipase A Antibody [Biotin]

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Lipase A Antibody [Biotin]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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