LITAF Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-00208

Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Peptide ELISA

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG

Concentration

0.5 mg/ml

View all LITAF Antibodies »

Product Specifications

Immunogen

Peptide with sequence C-PDGKGMNPPSYYTQ corresponding to internal region according to NP_001129945.1.

Reactivity Notes

xpected from sequence similarity: Mouse, Rat

Specificity

This antibody is excpected to crossreact with both reported isoforms (NP_004853.2; NP_001129945.1).

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for LITAF Antibody

Immunohistochemistry-Paraffin: LITAF Antibody [NBP1-00208]

Immunohistochemistry-Paraffin: LITAF Antibody [NBP1-00208]

Immunohistochemistry-Paraffin: LITAF Antibody [NBP1-00208] - (6.5ug/ml) staining of Thymus. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

Applications for LITAF Antibody

Application
Recommended Usage

Immunohistochemistry-Paraffin

6.5 ug/ml

Peptide ELISA

Detection limit 1:8000
Application Notes
WB: Preliminary experiments gave an approx. 25 kDa band in human lymph node lysates and in lysates of HeLa and HepG2 after 0.1 ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 17.1 kDa band according to NP_004853.2. The 25 kDa band was successfully blocked by incubation with the immunizing peptide.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: LITAF

Lipopolysaccharide is a potent stimulator of monocytes and macrophages, causing secretion of tumor necrosis factor-alpha (TNF-alpha) and other inflammatory mediators. This gene encodes lipopolysaccharide-induced TNF-alpha factor, which is a DNA-binding protein and can mediate the TNF-alpha expression by direct binding to the promoter region of the TNF-alpha gene. The transcription of this gene is induced by tumor suppresor p53 and has been implicated in the p53-induced apoptotic pathway. Mutations in this gene cause Charcot-Marie-Tooth disease type 1C (CMT1C) and may be involved in the carcinogenesis of extramammary Paget's disease (EMPD). Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq]

Long Name

Lipopolysaccharide-induced TNF Factor

Alternate Names

PIG7, SIMPLE, TP53I7

Entrez Gene IDs

9516 (Human); 56722 (Mouse); 65161 (Rat)

Gene Symbol

LITAF

UniProt

NP_004853.2 (Human)

Additional LITAF Products

Product Documents for LITAF Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for LITAF Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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