LRH-1/NR5A2 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-27196

Novus Biologicals, part of Bio-Techne
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NBP2-27196
NBP2-27196SS
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat, Porcine, Bovine, Canine, Chicken, Chinese Hamster, Equine, Guinea Pig, Opossum, Primate, Rabbit, Rhesus Macaque, Zebrafish

Cited:

Porcine

Applications

Validated:

Immunohistochemistry, Immunohistochemistry-Paraffin, Knockdown Validated, Western Blot

Cited:

Knockdown Validated, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

1.0 mg/ml

View all LRH-1/NR5A2 Antibodies »

Product Specifications

Immunogen

A portion of amino acids 140-190 from human NR5A2 was used as the immunogen for this antibody.

Reactivity Notes

Orangutan (100%), Chimpanzee (100%), New World Monkey (100%), Panda (100%), Great Ape (100%), Mole Rat (100%), White cheeked gibbon (100%), Platypus (100%), Zebra finch (100%), Catfish (100%), Frog (100%), Carolina anole (100%)

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for LRH-1/NR5A2 Antibody

Western Blot: LRH-1/NR5A2 Antibody [NBP2-27196]

Western Blot: LRH-1/NR5A2 Antibody [NBP2-27196]

Western Blot: LRH-1/NR5A2 Antibody [NBP2-27196] - Analysis of NR5A2 in HEPG2 lysate in the 1) absence and 2) presence of immunizing peptide, 3) mouse NIH3T3 and 4) RAW lysate probed with 3 ug/ml of NR5A2 antibody. Goat anti-rabbit Ig HRP secondary antibody and PicoTect ECL substrate solution were used for this test.
Immunohistochemistry-Paraffin: LRH-1/NR5A2 Antibody [NBP2-27196]

Immunohistochemistry-Paraffin: LRH-1/NR5A2 Antibody [NBP2-27196]

Immunohistochemistry-Paraffin: LRH-1/NR5A2 Antibody [NBP2-27196] - Analysis of NR5A2/LRH1 in human pancreas tissue using NR5A2/LRH1 antibody at 5 ug/ml.

Applications for LRH-1/NR5A2 Antibody

Application
Recommended Usage

Immunohistochemistry-Paraffin

5ug/ml

Knockdown Validated

reported in scientific literature (PMID 31978970)

Western Blot

1-5ug/ml~

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS

Preservative

0.05% Sodium Azide

Concentration

1.0 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: LRH-1/NR5A2

NR5A2 is a member of the so-called NR5A family of nuclear receptors. NR5A2, also call LRH1 or Liver Receptor Homolog 1, appears to play an important role in regulating pancreatic and embryonal stem cell differentiation maintaining a pluripotential or undifferentiated state. It also plays a role in controlling cholesterol balance (1, 2). NR5A2 may control pluripotentiality through its regulation of Oct4 and Nanog, both are commonly held as requisite factors for maintenance of stem cell undifferentiated states (3). Additionally, NR5A2 has a role in colon, pancreatic and breast cancer, accompanied by overexpression in the latter in ductal carcinomas (4, 5). Antibody to NR5A2 provides a tool to link expression and function with undifferentiated states in embryonic stem cells or in cancers of the breast, intestine, and pancreas, and for further characterization of NR5A2 as a potential biomarker.

Long Name

Liver Receptor Homolog 1/Nuclear Receptor Subfamily 5, Group A, Member 2

Alternate Names

B1F2, FTZ-F1 beta, LRH1, NR5A2

Gene Symbol

NR5A2

Additional LRH-1/NR5A2 Products

Product Documents for LRH-1/NR5A2 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for LRH-1/NR5A2 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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