LRRK2 Antibody (4E9)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-15156

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-15156
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Key Product Details

Species Reactivity

Validated:

Human

Applications

ELISA, Immunohistochemistry

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # 4E9

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all LRRK2 Antibodies »

Product Summary for LRRK2 Antibody (4E9)

Immunogen

A synthesized peptide derived from human LRRK2. UniProt ID (Q5S007).

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for LRRK2 Antibody (4E9)

Immunohistochemistry: LRRK2 Antibody (4E9) [NBP3-15156]

Immunohistochemistry: LRRK2 Antibody (4E9) [NBP3-15156]

Immunohistochemistry: LRRK2 Antibody (4E9) [NBP3-15156] - IHC image of LRRK2 antibody diluted at 1:100 and staining in paraffin-embedded human kidney tissue. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30 minutes at RT. Then primary antibody (1% BSA) was incubated at 4C overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

Applications for LRRK2 Antibody (4E9)

Application
Recommended Usage

Immunohistochemistry

1:50-1:200
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS (pH 7.4), 150mM NaCl, and 50% glycerol.

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20 to -80C. Avoid freeze-thaw cycles.

Background: LRRK2

LRRK2 is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8.

LRRK2 antibodies are useful tools for neurodegeneration research and certian kinase signaling pathway studies.

Long Name

Leucine-rich Repeat Ser/Thr Protein Kinase 2

Alternate Names

AURA17, Dardarin, PARK8, ROCO2

Gene Symbol

LRRK2

Additional LRRK2 Products

Product Documents for LRRK2 Antibody (4E9)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for LRRK2 Antibody (4E9)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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