Ly6C is a monocyte/macrophage and endothelial cell differentiation antigen regulated by interferon gamma, and may play a role in the development and maturation of lymphocytes. It is a member of the Ly6 multigene family of type V glycophosphatidylinositol anchored cell surface proteins. It is expressed on bone marrow cells, monocytes/macrophages, neutrophils, endothelial cells, and T cell subsets. Mice with the Ly6.2 allotype (e.g., AKR, C57BL, C57BR, C57L, DBA/2, PL, SJL, SWR, 129) have subsets of CD4+Ly6C+ and CD8+Ly6C+ cells, while Ly6.1 strains (e.g., A, BALB/c, CBA, C3H/He, DBA/1, NZB) have only CD8+Ly6C+ lymphocytes. This antibody is useful for the detection of macrophage precursor cells in the mid-stage development stage (late CFU-M, monoblasts and monocytes). It is highly suitable for the detection of monocytes in bone marrow samples by Flow Cytometry. ab15674 also identifies activated macrophages in inflammatory tissues where the simultaneous use of the murine pan-macrophage marker BM8 is recommended. This antibody also detects a wide range of endothelial cells.

Alternate Names

Ly 6c, Ly6c protein, Lymphocyte antigen 6 complex, Lymphocyte antigen 6 complex locus C, Lymphocyte antigen 6C, Lymphocyte antigen Ly 6C

Entrez Gene IDs

17067 (Mouse)

Gene Symbol

Ly6c1

UniProt

P0CW02 (Mouse), P0CW03 (Mouse)

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Product Documents for Ly-6C Antibody (ER-MP20) [Biotin]

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Product Specific Notices for Ly-6C Antibody (ER-MP20) [Biotin]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Ly-6C Antibody (ER-MP20) [Biotin]

Novus Biologicals, part of Bio-Techne | Catalog # NB100-64203

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Applications for Ly-6C Antibody (ER-MP20) [Biotin]

Flow Cytometry

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Background: Ly-6C